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Senior Scientist, Protein Engineering

Company: Yoh, A Day & Zimmermann Company
Location: San Diego
Posted on: February 23, 2021

Job Description:

Yoh has an exciting opportunity for an experienced-Senior Scientist-with expertise in Bioinformatics & Protein Engineering-to join our Client's team in San Diego, CA. This well-funded, highly-buzz-about Biotech Startup is focused on developing targeted gene therapies for aging and age-related diseases.-This individual will be tasked with their own project area and will assist with virus creation and running assays.

See below for complete job responsibilities and requirements. If after reviewing, you are interested in learning more about this, or other opportunities in Biotech,-please apply with your updated resume ASAP.-

Title:-Senior Scientist, Protein Engineering
Salary: Competitive/generous
Location:-San Diego, CA/Remote
Type: Full time, direct hire; open to consultants


  • Execute protein engineering projects based on structure function relationships
  • Measure protein-ligand binding interactions
  • Use of Rosetta to explore protein space for experimental design
  • Perform directed evolution experiments (e.g. yeast display, phage display, etc)
  • Design and build DNA (plasmids, genomic constructs, etc)
  • Screen and identify improved proteins based on FACS and/or biochemical analysis
  • Handle complex protocols, assist in experimental design, data analysis, and be able to summarize findings into technical reports
  • Maintain professional, scientific, and ethical integrity
  • Communicate effectively within the group and with other functional groups in the company
  • Setting, completing and updating milestones related to main project.
  • Executing experiments, independently and in conjunction with a small team in support of research studies.


    • Ph.D. in biology, biochemistry, microbiology, biomedical engineering, bioengineering, chemical engineering or related field required.
    • Experience w/ protein structure function relationships and experience with Rosetta modeling software is a MUST (or similar modeling software).
    • Ideal candidate will start out as 50/50 wet lab/computing.
    • Preferred Qualifications:

      • Experience with synthetic biology, directed evolution, protein engineering, library preparation and barcoding, screening methodologies, and next gen sequencing is preferred.
      • Design optimization of in vitro enzyme assays
      • Native and affinity-based protein purifications
      • Biophysical characterization of ligand binding
      • Molecular cloning and plasmid construction: Isothermal assembly
      • Golden gate, restriction-based and/or homologous recombination-based cloning
      • Well-organized, self-motivated, and a quick learner who is able to handle multiple projects simultaneously.
      • Willingness to work outside of his/her discipline to accomplish project goals.
      • Ability to work independently as well as in a collaborative team environment.
      • Strong work ethic, communication skills and goal-oriented personality.

        Yoh, a Day & Zimmermann company, is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, or status as a protected veteran. Visit to contact us if you are an individual with a disability and require accommodation in the application process.PandoLogic. Keywords: Senior Scientist, Location: San Diego, CA - 92108

Keywords: Yoh, A Day & Zimmermann Company, San Diego , Senior Scientist, Protein Engineering, Engineering , San Diego, California

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