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SRA and Scientist - Fermentation engineering

Company: Cellibre
Location: San Diego
Posted on: June 15, 2019

Job Description:

Cellibre is a cellular agriculture company that employs an organism-agnostic approach to turn cells into specialized, sustainable factories for the manufacture of globally significant products at scale. Our world-class scientific team has led programs from napkin to commercial, pioneering revolutionary breakthroughs in energy, ingredients, medicines and more. Cellibre's initial strategic focus will be deploying our expertise to enable the production of pharmaceutical-grade cannabinoids, alleviating the need for agriculture entirely and revolutionizing the way cannabinoid-based medicines are sourced, produced and consumed. We are seeking a research associate or scientist with experience in microbial fermentations for process optimization and testing of engineered strains. S/he will be responsible for running, maintaining and operating fermentation equipment and should be familiar with all aspects of microbial fermentation process including media preparation, operation of usual stirred fermenters, troubleshooting etc. We want team members with a natural inclination to challenge and work within a culture that is dynamic and self-directed. NOTE: For all positions posted by Cellibre, education is listed as required but can be overcome with experience. Please do not let education requirements dissuade you from applying for positions for which you think are you qualified on that metric. Required responsibilitiesScientistDesign and perform batch or continuous fermentations of yeast and bacteriaOptimize culturing conditions and media formulation to maximize product titer and yield of engineered strainsIdentify key parameters and conditions to scale down of fermentations in order to increase throughput RA/SRAOperate 1-15 L stirred tank fermenters including routine maintenance and troubleshootingPrepare fermentation media and buffers, sterilize and clean fermentation equipmentPerform small scale (shake flask, microwell plate) studies to optimize different process parameters and media componentsPerform sample processing and routine biochemical analysisPlay a role in the design and execution of scale-up/scale-down fermentation experimentsCollaborate with microbiologists and biochemists for strain validation and characterization Experience ScientistMS/PhD in Microbiology, Genetics, Biochemical Engineering or related discipline with more than two (2) years of experience in microbial fermentation technology and process development (experience with scale-up and tech transfer will be a plus)Experience in running, maintaining and troubleshooting of bench scale (1-10 L) microbial stirred tank fermenters (New Brunswick, Sartorius, Dasgip etc.)Experience with scale down models for increasing the throughput and quickly testing and optimizing fermentation conditions (substrate feeding rates, dissolved oxygen etc.), media formulation etc.Experience in optimizing fermentation conditions of yeast, fungi or other eukaryotic or prokaryotic microbes for the purpose of manufacturing of small molecules or APIsStrong understanding of the connection between cell physiology and fermentation process performance-- Being a strong contributor in highly cross-functional efforts who is not afraid to step in and lead a technical project RA/SRABachelor/MS degree in microbiology, bioengineering, chemical/biochemical engineering or a related field with 1-5 years of biotech industry or relevant academic experienceStrong understanding of fermentation principles and engineering fundamentals of growing recombinant microorganisms (yeasts, bacteria) in a bioreactorExperience with the setup and operation of various microbial fermentation processes with computer-controlled fermentation systems. Hands-on experience with different scales of fermenters is a plusExperience using lab automation (i.e. robotic systems) to enable complicated or high-throughput protocols is preferredExperience in operating lab-scale downstream processing techniques such as centrifugation, homogenization, and TFF/UF is preferredExperience with microbial culture and aseptic techniquesDemonstrated ability to design and perform experiments with minimal supervision.Demonstrated ability to approach solutions by systematic troubleshootingDemonstrated ability to work in a multidisciplinary research teamAbility to think proactively, independently, critically and creativelyExcellent collaboration, communication (oral and written) and multitasking skillsGoal-oriented, organized individual with a strong desire to a fast-paced dynamic research and development environment

Keywords: Cellibre, San Diego , SRA and Scientist - Fermentation engineering, Engineering , San Diego, California

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