Director, DMPK-Drug Discovery

Company: Yoh, A Day & Zimmermann Company
Location: La Jolla
Posted on: January 15, 2021

Job Description:

Yoh is a seeking a Director, DMPK-Drug Discovery
to support a San Diego Area based clinical staged oncology company.


Title: Director, DMPK-Drug Discovery

Location: San Diego, Ca (Relocation Offered)

Type: Permanent

Pay: Competitive, depends on experience


Essential Functions


Direct DMPK capability in-house and through external oversight, leading the overall scientific, technical, and operational efforts supporting research programs
Provide scientific guidance on lead optimization of programs and work in close collaboration with other research colleagues to optimize and evaluate the DMPK properties of candidate drugs
Define appropriate studies/endpoints and design of internal DMPK studies and be responsible for the deliverables from external studies
Ensure complete preclinical assessment of the ADME properties of candidate molecules and responsible for assembling high-quality data packages to support candidate selection and IND submission
Responsible for, the structural elucidation, understanding routes of elimination, levels, and identity of circulating metabolites to support toxicology studies
Will be responsible for scientific/technical aspects as well as management of assigned studies including protocol development, budget, timelines, oversight of outsourced activities, data analysis/interpretation, and report writing
Provide supervision, development, and mentorship to the Research DMPK group


Qualifications


Ph.D. in pharmaceutics, biochemistry, chemistry, or related discipline, with 10+ years of extensive training and industry experience in bioanalysis, metabolism, and pharmacokinetics supporting drug discovery environment with program team representation
A strong background in DMPK and pharmacokinetics/pharmacodynamics as applied to small molecule drug discovery
Extensive knowledge of metabolic routes of biotransformation, metabolite identification, and the chemistry of drug metabolism are required
Technical knowledge in multiple DMPK areas and an in-depth understanding of the experimental DMPK methodologies and approaches utilized in optimizing the ADME properties of small-molecule oral drugs, preferably in oncology
Highly effective organizational skills and detail-oriented with the ability to understand, plan, and navigate in a matrixed environment
Strong interpersonal and communication skills including exceptional collaboration and relationship management skills
Independent researcher with excellent time and people management capabilities and who is seeking to be a critical part of and to help lead cross-functional teams to support the company's drug discovery projects
A documented history of scientific & research impact in drug discovery
Able to provide strategic scientific input, and contribute to the decision-making process


Educational Requirements


Doctoral degree (Ph.D.) in biology, analytical chemistry, biochemistry, or relevant discipline
Proficient in the use of WinNonLin, GastroPlus/ADMET Predictor--, Microsoft Word, Excel, and PowerPoint
Familiarity with LIMS systems .


Yoh, a Day & Zimmermann company, is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, or status as a protected veteran. Visit https://www.yoh.com/applicants-with-disabilities to contact us if you are an individual with a disability and require accommodation in the application process.PandoLogic.Category: Healthcare, Keywords: Oncology Director

Keywords: Yoh, A Day & Zimmermann Company, San Diego , Director, DMPK-Drug Discovery, Executive , La Jolla, California