Director, DMPK-Drug Discovery
Company: Yoh, A Day & Zimmermann Company
Location: Solana Beach
Posted on: January 15, 2021
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Job Description:
Yoh is a seeking a Director, DMPK-Drug Discovery
to support a San Diego Area based clinical staged oncology
company.
Title: Director, DMPK-Drug Discovery
Location: San Diego, Ca (Relocation Offered)
Type: Permanent
Pay: Competitive, depends on experience
Essential Functions
Direct DMPK capability in-house and through external oversight,
leading the overall scientific, technical, and operational efforts
supporting research programs
Provide scientific guidance on lead optimization of programs and
work in close collaboration with other research colleagues to
optimize and evaluate the DMPK properties of candidate drugs
Define appropriate studies/endpoints and design of internal DMPK
studies and be responsible for the deliverables from external
studies
Ensure complete preclinical assessment of the ADME properties of
candidate molecules and responsible for assembling high-quality
data packages to support candidate selection and IND submission
Responsible for, the structural elucidation, understanding routes
of elimination, levels, and identity of circulating metabolites to
support toxicology studies
Will be responsible for scientific/technical aspects as well as
management of assigned studies including protocol development,
budget, timelines, oversight of outsourced activities, data
analysis/interpretation, and report writing
Provide supervision, development, and mentorship to the Research
DMPK group
Qualifications
Ph.D. in pharmaceutics, biochemistry, chemistry, or related
discipline, with 10+ years of extensive training and industry
experience in bioanalysis, metabolism, and pharmacokinetics
supporting drug discovery environment with program team
representation
A strong background in DMPK and pharmacokinetics/pharmacodynamics
as applied to small molecule drug discovery
Extensive knowledge of metabolic routes of biotransformation,
metabolite identification, and the chemistry of drug metabolism are
required
Technical knowledge in multiple DMPK areas and an in-depth
understanding of the experimental DMPK methodologies and approaches
utilized in optimizing the ADME properties of small-molecule oral
drugs, preferably in oncology
Highly effective organizational skills and detail-oriented with the
ability to understand, plan, and navigate in a matrixed
environment
Strong interpersonal and communication skills including exceptional
collaboration and relationship management skills
Independent researcher with excellent time and people management
capabilities and who is seeking to be a critical part of and to
help lead cross-functional teams to support the company's drug
discovery projects
A documented history of scientific & research impact in drug
discovery
Able to provide strategic scientific input, and contribute to the
decision-making process
Educational Requirements
Doctoral degree (Ph.D.) in biology, analytical chemistry,
biochemistry, or relevant discipline
Proficient in the use of WinNonLin, GastroPlus/ADMET Predictor--,
Microsoft Word, Excel, and PowerPoint
Familiarity with LIMS systems .
Yoh, a Day & Zimmermann company, is an Equal Opportunity Employer.
All qualified applicants will receive consideration for employment
without regard to race, color, religion, sex, sexual orientation,
gender identity, national origin, disability, or status as a
protected veteran. Visit
https://www.yoh.com/applicants-with-disabilities to contact us if
you are an individual with a disability and require accommodation
in the application process.PandoLogic.Category: Healthcare,
Keywords: Oncology Director
Keywords: Yoh, A Day & Zimmermann Company, San Diego , Director, DMPK-Drug Discovery, Executive , Solana Beach, California
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