Director, Chemical Biology
Company: Vertex Pharmaceuticals Inc (US)
Location: San Diego
Posted on: January 15, 2021
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Job Description:
Vertex is seeking a proven scientific leader in Chemical Biology
for our San Diego research facility. You will report to the head of
chemistry and will be a member of the chemistry leadership team.
This will include leading a multi-disciplinary team of scientists
to design and synthesize compounds that can probe novel drug
binding sites and elucidate the chemical features required for
activity without the constraints of developing a drug candidate. If
you have a proven track record in Chemical Biology as demonstrated
by peer reviewed publications and influence in the field, we would
welcome the opportunity to consider you for this newly created
leadership role with us.Key Responsibilities:* Integrate team
activities with drug research projects and clearly articulate and
communicate key questions that chemistry can help answer.* Develop
knowledge of and make recommendations about future applications of
chemistry to tackle new types of targets, such as DNA or RNA.* Stay
fluent with recent developments in the Chemical Biology field
including advances in tagging proteins (preferably in live cells),
biochemical and/or biophysical assay development and the rapidly
evolving field of protein degradation.Minimum Qualifications:* PhD
in Chemistry or Biology and 10+ years of experience; 3-5 years'
experience leading a small or mid-sized group preferably in an
industrial setting* Demonstrated contributions in target and drug
binding site identification and validation* Expertise in cell and
molecular biology, biochemistry, and pharmacology and broad
understanding of drug discovery* Expertise in biochemical and/or
biophysical tools to evaluate small molecule drug binding to target
protein* Experience in the application of genetic and/or
computational methods to study pathways and identify targets*
Expertise in chemistry, especially as it relates to probe design
and/ or tissue targeting* Proven experience developing and
mentoring group members* Effective communication skills, both
verbal and writtenPreferred Qualifications:* Experience in target
and drug binding site validation and/or identification* Experience
in planning, project leadership, laboratory and budget management*
Shown ability to champion and advance creative concepts* Ability to
manage complexity and ambiguity in a highly matrixed work
environment* Ability to identify and lead collaborations in
chemical biology field* A desire to be part of a highly innovative
and dynamic company aimed at transforming the lives of people with
serious diseases, their families and society
Keywords: Vertex Pharmaceuticals Inc (US), San Diego , Director, Chemical Biology, Executive , San Diego, California
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