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Director/Sr. Director, Discovery Oncology

Company: Bristol Myers Squibb
Location: San Diego
Posted on: May 16, 2022

Job Description:

At Bristol Myers Squibb, we are inspired by a single vision - transforming patients' lives through science. In oncology, hematology, immunology and cardiovascular disease - and one of the most diverse and promising pipelines in the industry - each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.The Oncogenesis Thematic Research Center at BMS is one of the fundamental research and early development engines delivering oncology therapeutics to patients. The Oncogenesis TRC has a major focus of exploiting BMS' expertise in protein degradation to discover and develop therapies aimed at tumor intrinsic vulnerabilities and mechanisms of resistance to existing cancer therapeutics. This focus on protein degradation allows us to attack protein classes that were previously deemed undruggable. The group integrates discovery research through translational and early clinical development and exploits state-of-the-art in vitro, in vivo and ex-vivo models of cancer biology to identify and validate targets and partners closely with colleagues in Translational Development, Informatics and Predictive Sciences and Early Clinical Development to generate biomarker and patient enrichment hypotheses to enable efficient decision making in early clinical trials.This Director/Sr. Director level position will join the discovery team at Bristol-Myers Squibb at the Oncogenesis Thematic Research Center in San Diego, CA. This position represents a unique opportunity to work with a team of innovative scientists and leaders in the targeted protein degradation field to make a meaningful impact on cancer patients lives.We are seeking a strong cancer biologist with a desire to pursue novel targets by leveraging the targeted protein degradation modality which greatly expands the realm of accessible targets. The successful candidate will lead a department of scientists who are prosecuting multiple novel drug discovery programs and collaborating with informatics, clinical and translational colleagues to leverage machine learning computational techniques to identify and validate novel hematologic and solid tumor cancer dependencies. The team reporting to this position have deep expertise in patient derived models, drug discovery, novel MoA research and target ID/validation. This position will report into the head of Discovery Oncology, be a member of the leadership team, and participate in leading internal and external collaborations. This position has significant opportunities for creativity and development.The successful candidate will demonstrate strong verbal and written communication skills, capable of presenting scientific results to multidisciplinary teams, senior management and at external scientific meetings. The candidate will develop external partnerships/collaborations to advance programs and platforms, as appropriate. They will be responsible for supervising a research team and participating in portfolio strategy. This position is in San Diego, CA, an important innovation hub for BMS.Preferred Qualifications

  • A Ph.D. degree with 10+ years of relevant academic or industry research experience in cancer biology and genetics, and/or oncology target ID, validation and drug discovery
  • Enthusiasm for novel drug modalities
  • Deep understanding of molecular drivers of cancer
  • Experience with preclinical models of cancer (in vitro/in vivo)
  • Familiarity with CRISPR based screens to interrogate targets and biological pathways
  • A proven track record in the field of cancer biology/genetics, as evidenced by publication record and/or successful advancement of molecules to clinical development
  • Ability to effectively communicate and collaborate colleague in other functional areas; including with informatics and translational research scientists to generate testable hypotheses to validate novel targets, identify and develop patient selection hypotheses
  • An effective manager and mentor to more junior PhDs and associates. Experience leading a large team.
  • Excellent oral and written communication skills, as well as the ability to effectively present scientific data and concepts to international standards.
  • Familiarity with targeted protein degradation, intrinsic degraders or molecular glue approaches desired
  • Experience or the ability to innovate in novel preclinical in vitro, in vivo and ex vivo oncology model development and functional screens that enables bridging from tumor biology to host immunityReports
    • 14 total reports, 5+ Ph.D.Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.Physical presence at the BMS worksite or physical presence in the field is an essential job function of this role which the Company deems critical to collaboration, innovation, productivity, employee well-being and engagement, and enhances the Company culture.To protect the safety of our workforce, customers, patients and communities, the policy of the Company requires all employees and workers in the U.S. and Puerto Rico to be fully vaccinated against COVID-19, unless they have received an exception based on an approved request for a medical or religious reasonable accommodation. Therefore, all BMS applicants seeking a role located in the U.S. and Puerto Rico must confirm that they have already received or are willing to receive the full COVID-19 vaccination by their start date as a qualification of the role and condition of employment. This requirement is subject to state and local law restrictions and may not be applicable to employees working in certain jurisdictions such as Montana. This requirement is also subject to discussions with collective bargaining representatives in the U.S.Our company is committed to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace adjustments and ongoing support in their roles. Applicants can request an approval of accommodation prior to accepting a job offer. If you require reasonable accommodation in completing this application or if you are applying to a role based in the U.S. or Puerto Rico and you believe that you are unable to receive a COVID-19 vaccine due to a medical condition or sincerely held religious belief, during or any part of the recruitment process, please direct your inquiries to Visit to access our complete Equal Employment Opportunity statement.Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.

Keywords: Bristol Myers Squibb, San Diego , Director/Sr. Director, Discovery Oncology, Executive , San Diego, California

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