Head of Structural Bioinformatics (Associate Director)

Company: Takeda Pharmaceutical
Location: San Diego
Posted on: September 24, 2022

Job Description:

By clicking the "Apply" button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda's Privacy Notice and Terms of Use . I further attest that all information I submit in my employment application is true to the best of my knowledge. Job Description About the role: The Head of Structural Bioinformatics will lead a dynamic and highly collaborative team of scientists that apply broad skillsets in computational biology, bioinformatics, new machine learning algorithms to identify RNA elements as targets for small molecule and oligonucleotide programs. The team will also design and optimize DNA, RNA and peptide/protein constructs and apply those methods for small molecule, oligo, gene therapy, cell therapy and biologics projects. The candidate will contribute to external research partnerships in addition to internal programs and will work effectively in a matrixed organization with colleagues across functions to directly contribute to Takeda's R&D pipeline. Join Takeda as a Head of Structural Bioinformatics in our Bioinformatics team, based in San Diego, CA. ACCOUNTABILITIES

• In collaboration with Drug Discovery Units, Global Biologics and Drug Discovery Sciences lead the design, analysis, and interpretation of studies to optimize molecules for different modalities e.g., small molecule, gene therapy, oligonucleotide
• In partnership with DDS teams create strategies to identify targetable RNA elements for the development of small molecule and oligonucleotide programs. These will include support and expansion of internal databases, integration of diverse experimental data sets and generation of structural RNA models.
• Work collaboratively with data scientists and informatics teams across the organization to enhance integrative analytic pipelines to support R&D computational biology strategy
• Partner effectively with teams across research functions and deliver results by working within a matrixed model
• Play an active role as subject matter expert in diligence of external opportunities
• Ensure effective integration with researchers for the collaborative interpretation of data
• Prepare and present comprehensive technical reports and scientific reports for internal meetings in all settings and with participants of all levels of the organization, as well as for external audiences as needed.
• Establish partnership with and maintain a collaborative, integrated role with project teams to influence the experimental design, assays needed, data generation, analysis, integration, and interpretation.
• Ensure the appropriate conduct of studies, lead the interpretation of study results, and prepare study reports suitable for internal or regulatory use
• Scientifically assess and recommend vendors, and outsource studies to appropriate contract research organizations DIMENSIONS AND ASPECTS
  • Proven expertise in development and implementation of state-of-the-art machine learning approaches in computational biologics (protein/RNA/DNA) design, developability prediction and optimization.
  • Demonstrated statistical modeling and machine learning experience for rational design of RNA therapeutics, protein engineering and other emerging modalities. Bioinformatics expertise spanning areas from sequence design, structure modelling, as well as omics analysis.
  • Strong scientific understanding of molecular biology, Next Generation Sequencing technologies and single cell -omics.
  • Able to develop in-silico data strategy and creative methods for integration of multi-omic and genome wide data.
  • Demonstrated experience with large-scale omics and high-throughput data analysis, network analysis, and meta-analyses.
  • Experience in computational method implementation and algorithm generation.
  • Able to evaluate/develop computational methods based on project needs.
  • Demonstrates broad technical program knowledge
  • Demonstrates effective people and project management skills Decision-making and Autonomy
    • Independently design, implement and/or oversee extensive, complex projects
    • Determine methods on new assignments and makes strategic recommendations on projects through demonstrated independence
    • Self-starting and supportive of team-based research and able to work effectively in a matrix organization.
    • Establish project direction integrating science, key technical knowledge, and program objectives
    • Ability to apply creative thinking to determine and implement solutions to complex problems
    • Proactively implement new methods, approaches, technologies based on current state of the field.
    • Proven track record of driving a significant scientific or technological project to success.
    • Experience in designing and conducting computational analysis strategy to meet program objectives; able to provide input on timelines and resource needs.
    • Provides information to group to influence direction, departmental goals and/or businessMinimum Requirements/Qualifications:
      • PhD degree in Systems Biology, Bioinformatics or Computational Biology with 7+ years post-doctoral experience, or
      • MS with 13+ years' experience, or
      • BS with 15+ years' experience
      • 5 years of Industry experience required
      • 5 years of managerial experience required
      • Experience with single cell and spatial transcriptomics or spatial high content imaging data, and standard genomic analyses workflows.
      • Familiar with public domain biological data sources and programmatic interfaces (API).
      • Fluency in at least one programming language (e.g., R, Python) commonly used for statistical and computational -omics analysis.
      • Solid knowledge of Unix/Linux, command line interfaces, and fluency in some common scripting and/or programming language.
      • Familiarity with parallel computing, relational databases (e.g., SQL), and cloud computing or distributed computing (Amazon Web Services).What Takeda can offer you:
        • Comprehensive Healthcare: Medical, Dental, and Vision
        • Financial Planning & Stability: 401(k) with company match and Annual Retirement Contribution Plan
        • Health & Wellness programs including onsite flu shots and health screenings
        • Generous time off for vacation and the option to purchase additional vacation days
        • Community Outreach Programs and company match of charitable contributions
        • Family Planning Support
        • Flexible Work Paths
        • Tuition reimbursementMore about us:At Takeda, we are transforming patient care through the development of novel specialty pharmaceuticals and best in class patient support programs. Takeda is a patient-focused company that will inspire and empower you to grow through life-changing work.Certified as a Global Top Employer, Takeda offers stimulating careers, encourages innovation, and strives for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world.In accordance with the CO Equal Pay Act, Colorado Applicants Are Not Permitted to Apply.EEO Statement Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law. Locations San Diego, CABoston, MA Worker Type Employee Worker Sub-Type Regular Time Type Full time

Keywords: Takeda Pharmaceutical, San Diego , Head of Structural Bioinformatics (Associate Director), Executive , San Diego, California