Structural Biologist (R5-R7)
Location: San Diego
Posted on: June 23, 2025
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Job Description:
At Lilly, we unite caring with discovery to make life better for
people around the world. We are a global healthcare leader
headquartered in Indianapolis, Indiana. Our employees around the
world work to discover and bring life-changing medicines to those
who need them, improve the understanding and management of disease,
and give back to our communities through philanthropy and
volunteerism. We give our best effort to our work, and we put
people first. We’re looking for people who are determined to make
life better for people around the world. Eli Lilly and Company
seeks a Structural Biologist (R5-R7) to support structure-based
drug discovery (SBDD)projects focused on G protein-coupled
receptors (GPCRs). Perform structure determination and drug design
for GPCR and membrane protein targets as well as soluble protein
targets. Apply biochemical, biophysical, and computational
techniques to accelerate generation of high-quality reagents for
X-ray crystallography and cryogenic electron microscopy (cryo-EM)
studies. Determine structures and co-complex structures of protein
targets for the design of small-molecule and antibody therapeutics.
Develop integrative approaches to SBDD incorporating data and input
from structural biology, biophysics, protein biochemistry, and
medicinal chemistry teams. LI-DNI Position requires a Ph.D. in
Structural Biology, Biophysics, Biochemistry, Chemistry, or a
related field, and 2 years of academic or employment experience
with GPCR biology, pharmacology, and structure-based research
studies of GPCRs. Academic or employment experience must include a
minimum of: 2 years of experience with protein engineering, protein
biochemistry, and protein structure determination by X-ray
crystallography or cryo-EM; 2 years of experience with construct
design, molecular cloning, and protein expression and purification;
2 years of experience with chromatographic methods for isolating
recombinant proteins and HPLC/FPLC systems; 2 years of experience
with SDS-PAGE, Western blot, thermal shift assays, and ELISA; and 2
years of experience with computational tools for protein structure
determination and analysis, including CCP4, Phenix, COOT, PyMol,
and Chimera. Part time telecommuting may be permitted. Up to 10%
domestic and international travel required. LI-DNI Job location:
San Diego, CA. RATE OF PAY: $168,709.00 - $178,709.00 per year. To
apply, please visit https://jobsearch.lilly.com/ and enter job
requisition number R-84158 when prompted. Alternatively, please
send your resume, cover letter, and a copy of the ad to: Beth L.
Berry, Lilly Corporate Center, Indianapolis, IN 46285. Lilly is
dedicated to helping individuals with disabilities to actively
engage in the workforce, ensuring equal opportunities when vying
for positions. If you require accommodation to submit a resume for
a position at Lilly, please complete the accommodation request form
( https://careers.lilly.com/us/en/workplace-accommodation ) for
further assistance. Please note this is for individuals to request
an accommodation as part of the application process and any other
correspondence will not receive a response. Lilly is proud to be an
EEO Employer and does not discriminate on the basis of age, race,
color, religion, gender identity, sex, gender expression, sexual
orientation, genetic information, ancestry, national origin,
protected veteran status, disability, or any other legally
protected status. Our employee resource groups (ERGs) offer strong
support networks for their members and are open to all employees.
Our current groups include: Africa, Middle East, Central Asia
Network, Black Employees at Lilly, Chinese Culture Network,
Japanese International Leadership Network (JILN), Lilly India
Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ
Allies), Veterans Leadership Network (VLN), Women’s Initiative for
Leading at Lilly (WILL), enAble (for people with disabilities).
Learn more about all of our groups. Actual compensation will depend
on a candidate’s education, experience, skills, and geographic
location. The anticipated wage for this position is 168,709.00 -
178,709.00 Full-time equivalent employees also will be eligible for
a company bonus (depending, in part, on company and individual
performance). In addition, Lilly offers a comprehensive benefit
program to eligible employees, including eligibility to participate
in a company-sponsored 401(k); pension; vacation benefits;
eligibility for medical, dental, vision and prescription drug
benefits; flexible benefits (e.g., healthcare and/or dependent day
care flexible spending accounts); life insurance and death
benefits; certain time off and leave of absence benefits; and
well-being benefits (e.g., employee assistance program, fitness
benefits, and employee clubs and activities).Lilly reserves the
right to amend, modify, or terminate its compensation and benefit
programs in its sole discretion and Lilly’s compensation practices
and guidelines will apply regarding the details of any promotion or
transfer of Lilly employees. WeAreLilly
Keywords: , San Diego , Structural Biologist (R5-R7), Executive , San Diego, California
