Research Associate/Senior Research Associate, Cell Therapy Research

Company: Tanabe Research Laboratories U.S.A, Inc.
Location: San Diego
Posted on: January 16, 2022

Job Description:

Tanabe Research Laboratories USA (www.trlusa.com) located in San Diego, California is a cutting edge biotechnology company dedicated to the discovery and advancement of innovative therapies to treat cancer and other serious diseases. This position is located onsite at our San Diego facility.--JOB SUMMARY:------------------ Independently responsible or with little assistance conducts a scientific study using standard to advanced cell biology and molecular biology techniques.--ESSENTIAL DUTIES AND RESPONSIBILITIES:

• May propose, initiate, and execute biologic pre-clinical drug development projects working towards cellular therapy product development using existing expertise at TRL.
• Contributes towards developing, executing and documenting methodologies for isolating and modifying NK and other cell types from various sources including iPSCs.
• Experience in differentiating iPSCs into NK and other cell types for product development would be preferred.
• Experience in cell culture and handling of primary effector cells towards product development using closed system instrumentation.
• Has knowledge and some experience with CRISPR/Cas based gene editing
• Experience with documentation towards tech transfer to CDMOs is preferred.
• Manage and perform activities such as immunofluorescence, flow cytometry, quantitative immunoassays, and other standard biologic laboratory techniques. --
• Contribute intellectually to strategies for automated methods for screening and identify and implement new technologies that will improve the efficiency and quality of applied methodologies.--
• Execute in vitro and in vivo experiments including PDX models and combinations studies for TRL's pipeline candidates to investigate potential cancer indications.
• Conduct experiments in support of TRL projects that could help developing an IND package for Phase I studies.
• May discover innovative technologies to improve the efficiency of laboratory operations.--
• Analyze and present data to scientific team for in depth discussions.
• Contribute to the identification and evaluation of new technologies.
• Integrates results into larger project goals and deliverables.
• Prepares reports and papers of completed projects or use in further research activities.
• Analyzes data and interprets results in clear format for presentation during project team meetings and project reviews.
• Appropriately documents research findings in lab notebooks.
• Keep current with appropriate scientific literature and contributes new ideas to advance project work.
• May interact with company consultants.--KNOWLEDGE/SKILLS/ABILITIES REQUIRED:
  • A BS/MS with 3-5 years of relevant experience, preferably in an industry setting.
  • Prior experience with cellular therapies is important. Experience with iPSC-based lymphocyte cell therapies, especially in an industry setting would be preferred. This would include expertise in handling instrumentation that comprise a closed system. Skilled at documentation with prior experience in tech transfer to CDMOs.
  • Experience with isolation and culturing of lymphocytes from various sources including iPSCs would be preferred.
  • Prior experience with product development involving modified NK or T cells would be preferred. Decent expertise with developing closed systems for product development and prior experience in preparing documentation towards tech transfer.
  • Knowledge and experience working with different cancer models both in vitro and in vivo are desired.
  • Significant experience with working in a team setting.
  • Well organized and has good experience in designing and documenting protocols and data generated from them in an industry setting
  • Experience conducting a wide variety of basic to complex experimental procedures.
  • Ability to independently design, document and execute experiments.
  • Ability to independently analyze and present data to scientific team.--
  • Excellent record keeping, attention to detail and communication skills.
  • Thorough knowledge of MS Office products.
  • Ability to work effectively with others in a team laboratory and office environment.
  • Ability to change tasks quickly and still maintain attention.

Keywords: Tanabe Research Laboratories U.S.A, Inc., San Diego , Research Associate/Senior Research Associate, Cell Therapy Research, Healthcare , San Diego, California