Scientist, Gene Therapy Analytical Development
Company: National Resilience
Location: San Diego
Posted on: January 16, 2022
This role will be responsible advancing Resilience R&D's
knowledge of gene therapy analytical methods through innovative
experimental design and efficient execution. The ideal candidate
will have a proven track record in successfully developing new
assay platforms and reagents, working closely with a
multidisciplinary team of scientists and engineers. They will be
design and perform experiments using state-of-the-art approaches -
integrating cutting edge technology, automation, and data science
where appropriate. This role requires excellent communication and
creativity, backed by a high level of velocity and rigor.
Drive innovation through development of novel analytical methods
and reagents, including new immunoassays (ELISA, western blot,
etc.), cell-based assays, qPCR/ddPCR, and LC-MS.
Design, execute, and interpret data from sophisticated experiments
and clearly communicate key findings to teams within Resilience
Perform assay validation and verification, as required.
Perform practical beta-testing of new applications and sensor
platforms developed by other technical teams.
Prepare and follow standard operating procedures, batch records,
and other process documentation.
Analyze and document experimental data in electronic laboratory
notebooks in a timely and accurate manner in accordance with the
company quality management system.
Mentor research associates in proper laboratory techniques and
scientific experimental design.
Attend and present scientific data to colleagues at internal
Participate in daily Agile stand-ups and weekly sprints with other
members of the research team.
PhD degree in Biology, Engineering, Medicine or related discipline
with 1-3 years of laboratory research or industry experience.
3+ years of expertise in vector manufacturing analytical
Extensive hands-on experience in ddPCR, qPCR, cell-based and
plate-based assays, and LC MS.
Familiarity with new modality sensor platforms (DLS+UV, mass
photometry, mass cytometry).
Demonstrated independent problem solving and systematic data-driven
experimental design and execution.
Demonstrated ability to clearly communicate technical information
and roadmaps through written protocols and/or presentations
containing clean figures and visualizations.
Innovative and analytical thinker with outstanding interpersonal,
communication, and leadership skill.
Must be highly disciplined and organized, self-motivated and
enthusiastic about taking a hands-on approach to collaborative
scientific discovery efforts.
Expertise in modern vector analytical approaches and platforms,
including qPCR, ddPCR, ELISA, LS-MS
Knowledge of viral vector design (AAV, Lentivirus, Gamma
retrovirus) and vector manufacturing processes.
Statistical analysis of genotypic, gene expression data in bulk and
single cell samples
Experience in setting up and working within a GxP environment
Exposure to pre-clinical R&D and IND filing requirements for a
cell and gene therapy products
Experience in interfacing with laboratory automation (e.g.
automated liquid handlers) and data analysis software.
Experience with coding and running bioinformatics scripts (Python,
numpy, scipy, pandas, jupyter).Bayesian analytics
Keywords: National Resilience, San Diego , Scientist, Gene Therapy Analytical Development, Healthcare , San Diego, California
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