Scientist, Next Generation Medicine Design
Company: Bristol-Myers Squibb
Location: San Diego
Posted on: June 25, 2022
Job Description:
At Bristol Myers Squibb, we are inspired by a single vision -
transforming patients' lives through science.In oncology,
hematology, immunology and cardiovascular disease - and one of the
most diverse and promising pipelines in the industry - each of our
passionate colleagues contribute to innovations that drive
meaningful change. We bring a human touch to every treatment we
pioneer. Join us and make a difference.Traditional targets and
modalities that have provided rich substrates for medicine design
and decades of productive industrial and academic research are not
the primary targets of the future. There is a slow but steady shift
in the target and modality landscape. Novel modalities such as
protein degradation is an intense and hot area of scientific
research.We are seeking exceptional scientific leaders who have
high energy, have high capacity to work in a rapid and fluid
research environment, innately curious and pro-active leaders with
versatile skills, to join the Molecular Structure & Design team
with a focus on driving our Protein Homeostasis portfolio of
projects. As part of our team, you would utilize structure-based
and ligand-based computational chemistry methods combined with data
visualization, data analysis, machine learning and AI techniques to
design molecules with superior degradation and pharmacological
properties.In collaboration with multi-disciplinary Protein
Degrader project teams, you will be expected to proactively lead
projects, generate testable hypotheses, lead/design/execute complex
computational experiments, provide in-depth analysis and
interpretation of results, and translate them into actionable
molecular designs that advance the discovery portfolio. Through
close collaboration, clear communication, and technical excellence,
you will work with scientists across the R&D organization to
influence the pipeline from target identification and degrader
optimization through to candidate nomination.Responsibilities will
include, but are not limited to, the following:
- Lead and influence the prospective use of computational methods
in rigorously evaluating therapeutic targets, protein degradation
modality and degrader designs within project teams.
- In close collaboration with project teams, develop and apply a
wide variety of design and computational methods to improve
potency, selectivity, protein degradation profiles and ADME
properties while minimizing toxicological risk and pro-actively
influence decision making on project teams.
- Significantly enhance understanding of SAR and contribute to
team strategy by assimilating and interpreting data using
structural modeling, AI/ML, statistical and
data-mining/data-visualization technologies.
- Develop and apply new approaches for designing
bioactive-relevant features using multi parameter optimization
methods.
- Pro-actively provide scholarship in early target space
vis----vis competitive information, literature/patent reviews and
mining, chemical matter feasibility assessment, target
feasibility/modality assessment, druggability/binding site
characterizations, as appropriate.
- Maintain and develop working knowledge of contemporary
computational chemistry methods and their application to discovery
projects.Background Requirements:
- A completed Ph.D. in computational chemistry or a related field
with strong application background as demonstrated by contributions
to leading journals
- A minimum of 2+ years of biotech/pharma industrial
experience.
- Demonstrated expertise in a subset of computational methods:
docking methods, molecular dynamics simulations, homology modeling
approaches, free energy simulations, AI/machine learning
techniques, statistical methods, large-scale data
visualization/analysis and multiple parameter optimization methods
and a familiarity with the rest.
- Demonstrated experience in applying computational methods to
diverse biological targets such as different protein families, DNA,
RNA using different modalities such as traditional modulators,
allosteric modulators, covalent agents, chimeric protein degraders,
molecular glues, antibodies, antibody-drug conjugates is
preferred.Scientific/Technical/Functional Skills:
- Demonstrated skills in the application of computer-assisted
drug design using standard modeling and computational software
packages
- Demonstrated ability to independently analyze literature and
project data, formulate creative design hypotheses, data analysis
and design novel agents in the context of project need.
- Demonstrated ability to serve as a lead computational chemist
on multiple discovery projects and be accountable for delivery of
project goals
- A working knowledge of medicinal chemistry and discovery
- Basic programming experience in at least one scripting language
(e.g., Perl, Python) or programming language (Java, C, C++)
- Excellent communication and organizational skills and ability
to work within a multidisciplinary team across geographic areas to
advance discovery projects are required
- Personal attributes of integrity, creativity, problem solving,
and strong work ethicAround the world, we are passionate about
making an impact on the lives of patients with serious diseases.
Empowered to apply our individual talents and diverse perspectives
in an inclusive culture, our shared values of passion, innovation,
urgency, accountability, inclusion and integrity bring out the
highest potential of each of our colleagues.Bristol Myers Squibb
recognizes the importance of balance and flexibility in our work
environment. We offer a wide variety of competitive benefits,
services and programs that provide our employees with the resources
to pursue their goals, both at work and in their personal
lives.Physical presence at the BMS worksite or physical presence in
the field is an essential job function of this role which the
Company deems critical to collaboration, innovation, productivity,
employee well-being and engagement, and enhances the Company
culture.To protect the safety of our workforce, customers, patients
and communities, the policy of the Company requires all employees
and workers in the U.S. and Puerto Rico to be fully vaccinated
against COVID-19, unless they have received an exception based on
an approved request for a medical or religious reasonable
accommodation. Therefore, all BMS applicants seeking a role located
in the U.S. and Puerto Rico must confirm that they have already
received or are willing to receive the full COVID-19 vaccination by
their start date as a qualification of the role and condition of
employment. This requirement is subject to state and local law
restrictions and may not be applicable to employees working in
certain jurisdictions such as Montana. This requirement is also
subject to discussions with collective bargaining representatives
in the U.S.Our company is committed to ensuring that people with
disabilities can excel through a transparent recruitment process,
reasonable workplace adjustments and ongoing support in their
roles. Applicants can request an approval of accommodation prior to
accepting a job offer. If you require reasonable accommodation in
completing this application or if you are applying to a role based
in the U.S. or Puerto Rico and you believe that you are unable to
receive a COVID-19 vaccine due to a medical condition or sincerely
held religious belief, during or any part of the recruitment
process, please direct your inquiries to . Visitto access our
complete Equal Employment Opportunity statement.Any data processed
in connection with role applications will be treated in accordance
with applicable data privacy policies and regulations.
Keywords: Bristol-Myers Squibb, San Diego , Scientist, Next Generation Medicine Design, Healthcare , San Diego, California
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