Senior Principal Scientist, T-Cell Immuno-Oncology
Location: La Jolla
Posted on: April 18, 2019
The T cell Immuno-Oncology (I-O) group in Pfizer is building a
world-class immunology team and is seeking a highly motivated and
creative Senior Principal Scientist to join a group of researchers
evaluating novel therapies in the fields of Cancer Immunotherapy,
Immune Checkpoint Biology, and Innate Immunity. The candidate will
report to the Senior Director, Cancer Immunology and work closely
with other disciplines across Pfizer to drive early discovery
research programs into early clinical development, providing
scientific and technical expertise. Specifically, the candidate
will identify unique tumor-specific micro-environmental cues that
impact T cell and dendritic cell function, differentiation and
trafficking using a variety of tools including, classic molecular,
cellular, and biochemical techniques, as well as modern imaging
techniques, systems immunology, bioinformatics, and preclinical in
vitro and in vivo models.
- Supervise research associates and/or scientists.
- Discover and develop new therapeutic modalities for cancer
- Design and perform studies to evaluate the anatomical
distribution, persistence and function of antigen-specific T cells
and dendritic cells in preclinical models of cancer.
- Design and execute mechanism of action, PD and other biomarker
studies, as well as combination studies for Pfizer's
preclinical-stage small molecule/IO drugs using in vivo murine
models and ex vivo methods, such as cell sorting, multi-color flow
cytometry, CyTOF, gene expression analysis techniques, and human
and murine primary cell culture.
- Collaborate with protein engineering, computational biology, T
cell redirecting therapy group and clinical development group to
pursue the most promising drug candidates through clinical
- Lead collaborations with internal and external
- Present at group meetings, global project team meetings, and
- Contribute to a dynamic, exciting culture that embraces
teamwork and innovation.
- Ph.D. with 8+ years of experience (prefer 8+ years of post-Ph.D
- Demonstrated expertise in the field of immunology, cell biology
- Solid technical knowledge and hands-on experience with
conventional immunological techniques.
- Broad experience in assessing T cell and/or DC function,
differentiation, and memory development.
- Expertise in flow cytometry, qRT-PCR, MSD, Nano string and
- Working knowledge of various murine tumor and/or infectious
- Ability to independently design, plan and execute and interpret
- Prior experience working with or leading collaborations with
external academic, biotechnology, and contract research
- Experience in mentoring and/or leading Ph.D. level and
non-Ph.D. level scientists.
- Ability to organize and communicate complex data sets in a
clear and concise manner to key stakeholders from diverse
- Excellent organization and planning skills, the ability to work
in a fast-paced environment independently or as part of a team,
good verbal and written communication, and strong motivation with a
dedicated work ethic.
- Ability to actively contribute scientifically to immunological
drug discovery research programs, including identification and
validation of novel targets.
- In-depth understanding of T cell subsets and surface markers -
Teff, Tem, Tcm,Trm, Treg Th1, Th2 etc.
- In-depth understanding of dendritic cell biology.
- In-depth understanding of inhibitory and co-stimulatory
molecules and their associated signal transduction pathways.
- Experience in CRISPR technology and lentiviral
- Experience with human PBMC and mammalian cell culture.
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licensed physicians may constitute a reportable transfer of value
under the federal transparency law commonly known as the Sunshine
Act. Therefore, if you are a licensed physician who incurs
recruiting expenses as a result of interviewing with Pfizer that we
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made currently will be reported to the government. If you have
questions regarding this matter, please do not hesitate to contact
your Talent Acquisition representative.
EEO & Employment Eligibility
Pfizer is committed to equal opportunity in the terms and
conditions of employment for all employees and job applicants
without regard to race, color, religion, sex, sexual orientation,
age, gender identity or gender expression, national origin,
disability or veteran status. Pfizer also complies with all
applicable national, state and local laws governing
nondiscrimination in employment as well as work authorization and
employment eligibility verification requirements of the Immigration
and Nationality Act and IRCA. Pfizer is an E-Verify employer.
Other Job Details:
- Eligible for Relocation Package
- Eligible for Employee Referral Bonus
Pfizer is an equal opportunity employer and complies with all
applicable equal employment opportunity legislation in each
jurisdiction in which it operates.
Keywords: Pfizer, San Diego , Senior Principal Scientist, T-Cell Immuno-Oncology, Healthcare , La Jolla, California
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