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Principal Software Engineer (Technical Lead)

Company: Illumina
Location: San Diego
Posted on: March 20, 2023

Job Description:

What if the work you did every day could impact the lives of people you know? Or all of humanity?

At Illumina, we are expanding access to genomic technology to realize health equity for billions of people around the world. Our efforts enable life-changing discoveries that are transforming human health through the early detection and diagnosis of diseases and new treatment options for patients.

Working at Illumina means being part of something bigger than yourself. Every person, in every role, has the opportunity to make a difference. Surrounded by extraordinary people, inspiring leaders, and world changing projects, you will do more and become more than you ever thought possible.

Illumina sequencers generate data on an enormous scale, and the process of transforming raw image data into actionable interpretations (known as "secondary analysis") is a critical challenge for all applications of genomics. As a company, we have key competitive advantages in our highly efficient, FPGA-accelerated approach to genomic analysis. Our approach to computation means that our customers save money, and even more importantly time: faster time to diagnosis can literally mean the difference between life and death.

The Principal Software Engineer plays a key role in leading the integration of Illumina secondary analysis into new Illumina sequencing instruments. As a technical leader, you will quickly come to understand the demands of the software and the possibilities and constraints of the hardware platforms, and do what it takes to deliver high-performance compute systems on new Illumina instruments.

You will succeed in this position through your quick technical understanding, your ability to listen and learn from a broad variety of technical experts, your ability to communicate clearly, and your ability to form relationships and build influence across the organization. It is a role that requires technical leadership qualities, without being a management role.

We need you to see risks, keep status clear, understand schedules, clarify requirements, help bring together the right people into conversation, and act as the hub and source of technical state of these richly complex integration projects.

This role is performed at our San Diego headquarters or hybrid onsite/remote in the San Diego market.

Key responsibilities:

  • Work closely with developers, project managers, and other stakeholders to ensure that the software designs meet the business and technical requirements of the project
  • Provide technical leadership to the project and development team
  • Develop and/or review software architecture plans
  • Ensure that the software designs are scalable, maintainable, and efficient
  • Work closely with the development teams to create and document technical designs
  • Identify and address potential technical risks and issues
  • Develop project plans, and ensure that projects are completed on time
  • Provide technical assistance to integration issues and escalated production issues and/or customer communication
  • Provide guidance and mentorship to developers on design and implementation
  • Keep up to date with the latest trends and developments in software architecture and technologies Key skills:
    • Typically requires an advanced degree in the engineering or scientific fields, with a minimum of 15 years of related experience
    • 10 years of experience driving technical projects to completion
    • Strong background in software development or systems engineering
    • Extensive experience with a variety of programming languages and technologies
    • Excellent communication and collaboration skills.
    • The ability to think strategically and solve complex problems
    • Demonstrated success in collaborating in a fast-paced team environment and delivering high-quality products against formal schedules
    • Have proven ability to self-manage, as well as manage interdisciplinary relationships

      Listed responsibilities are an essential, but not exhaustive list, of the usual duties associated with the position. Changes to individual responsibilities may occur due to business needs.


      The estimated base salary range for the Principal Software Engineer (Technical Lead) role based in the United States of America is: $180,100 - $270,100. Should the level or location of the role change during the hiring process, the applicable salary range may be updated accordingly. Compensation decisions are dependent on several factors including, but not limited to, an individual's qualifications, location where the role is to be performed, internal equity, and alignment with market data. Additionally, all employees are eligible for one of our variable cash programs (bonus or commission) and eligible roles may receive equity as part of the compensation package. We offer a wide range of benefits as innovative as our work, including access to genomics sequencing, family planning, health/dental/vision, retirement benefits, and paid time off.

      At Illumina, we strive to foster a diverse and inclusive workplace by cultivating an environment in which everyone contributes to our mission. Built on a strong foundation, Illumina has always been rooted in openness, collaboration, and seeking alternative views and perspectives to propel innovation in genomics. We are proud to confirm a zero-net gap in pay, regardless of gender, ethnicity, or race. We also have several Employee Resource Groups (ERG) that deliver career development experiences, increase cultural awareness, and demonstrate our collective commitment to diversity and inclusion in the communities we live and work. We are proud to be an equal opportunity employer committed to providing employment opportunity regardless of sex, race, creed, color, gender, religion, marital status, domestic partner status, age, national origin or ancestry, physical or mental disability, medical condition, sexual orientation, pregnancy, military or veteran status, citizenship status, and genetic information. If you require accommodation to complete the application or interview process, please contact To learn more, visit:

Keywords: Illumina, San Diego , Principal Software Engineer (Technical Lead), IT / Software / Systems , San Diego, California

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