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Scientist I, Analytical Development

Company: AveXis Inc.
Location: San Diego
Posted on: January 17, 2020

Job Description:

OverviewReady to join a team committed to moving gene therapies into the clinical and commercial settings for patients and families devastated by rare neurological genetic diseases? AveXis is advancing cutting-edge science to treat rare and life-threatening genetic diseases starting with our clinical-stage, proprietary gene therapy candidate, AVXS-101 (ZOLGENSMA--). We are in the midst of an incredible journey and are looking for passionate individuals to join us on this important mission.AveXis, Inc., a Novartis company, is a gene therapy company, dedicated to developing and commercializing novel treatments for patients suffering from rare and life-threatening neurological genetic diseases. Our initial product, ZOLGENSMA--, is our proprietary gene therapy product for the treatment of spinal muscular atrophy, or SMA, the leading genetic cause of infant mortality. In addition to developing AVXS-101 to treat SMA, we also plan to develop other novel treatments for rare neurological diseases, including Rett syndrome (RTT) and a genetic form of amyotrophic lateral sclerosis (ALS) caused by mutations in the superoxide dismutase 1 (SOD1) gene.AveXis is seeking a highly motivated and competent entry level Scientist to join the growing, dynamic multidisciplinary Analytical Development department. The person will contribute to the development and optimization of phase-appropriate bioassays for the lot release, stability testing and characterization of drug substance/drug product. In addition, he/she will participate in exploratory studies driving the evaluation of state-of-the-art new technology platforms, and innovative upgrades for existing assay platforms. Responsibilities

  • Planning and execution of experiments that contribute to bioassay development, optimization and qualification/validation, suitable for drug product stability studies and lot disposition.
  • Assist in authoring of technical reports and SOPs.
  • Support technology transfer of methods to internal QC group and/or CROs.
  • Work with junior research associates on experimental design, troubleshooting, assay optimization and data interpretation, as needed.
  • Interpret and present data at group and departmental meetings.
  • Collaborate within the Bioassay group and provide support to collaborating functional groups, as needed.
  • Participate in exploratory assay development efforts to bring new technologies or assays to the Analytical Development department. Qualifications
    • B.S., M.S. or Ph.D. in Cell Biology or related discipline, such as Immunology.
    • B.S. with 7-10 years or M.S. with 2-5 years (no more than 5 years) of biopharma industry experience, with knowledge and hands-on experience with various analytical methods
      • For example, Western Blot, ELISA, MSD, ELISpot, Flow Cytometry/FACS, Luminescence/Fluorescence plate-based assays, Immunofluorescence microscopy
      • Experience with High-Content imaging and image analysis is a plus, but not required.
      • High level of proficiency with Cell Culture standard methods such as aseptic technique, cell culture media preparation, maintenance of mammalian cell lines and cryopreservation.
      • Demonstrated proficiency in developing and optimizing bioassays independently with limited guidance by the senior scientist.
      • Ability to obtain frontier scientific knowledge and skills by learning from literature or conferences.
      • Demonstrated ability to work in a fast-paced, team-orientated environment with aggressive timelines.
      • Excellent written and verbal communication skills.
      • Experience and understanding of phase-appropriate analytical assay development, qualification, and validation obtained from 1-2 years of experience in GxP environment is a significant plus, but not required.
      • Experience with analytical and/or statistical software (e.g., JMP, Softmax Pro, XLfit, Gen5 etc.), is highly beneficial.
      • Ability to troubleshoot experiments based on thorough understanding of assay principles.
      • Familiarity with virology is a plus. The level of this position will be based on the final candidate's qualifications. Please note this job description is not designed to cover or contain a comprehensive listing of activities, duties or responsibilities that are required of the employee for this job. Duties, responsibilities and activities may change at any time with or without notice. AveXis is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity, national origin, genetics, disability, age, sexual orientation or veteran status. #LI-JH1

Keywords: AveXis Inc., San Diego , Scientist I, Analytical Development, Other , San Diego, California

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