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Principal Scientist, Analytical Development

Company: Synthorx, Inc.
Location: La Jolla
Posted on: March 28, 2020

Job Description:

Principal Scientist -Analytical Development Synthorx, a Sanofi Company, employs a novel synthetic biology platform for the discovery and development of transformational protein therapeutics for the treatment of cancer and autoimmune disorders. We are hiring a Principal Scientist with experience in protein analytics and in-depth knowledge of characterization to join the CMC team to advance drug candidates through clinical development and accelerate IND-enabling activities. The qualified candidate will report to the Senior Director of CMC Analytical and Formulation Development. Key Responsibilities: --- Design and implement methods for the characterization of PEGylated proteins, mAbs, antibody fragments and proteomics using state of art analytical technologies including LC/MS and MS/MS --- Apply extensive scientific knowledge and practical experience to develop separation methods, e.g. RP, IEX, HILIC, SEC and Protein A affinity chromatography for quantitative and qualitative analysis --- Apply extensive hands-on experience with various instrument and software including LC-Qtof mass spectrometry, nanoLC-MS/MS, Orbitrap MS, LC-SQD2, UVVIS spectrophotometer, etc. to support method development and quick data turnaround --- Perform LC-MS/MS method development in conjunction with optimal separation technologies to identify and quantitate Host Cell Proteins (HCPs) supporting HCP assay development and downstream process development --- Support characterization of PTMs and relative quantitation of unnatural amino acid incorporation throughout lead to drug candidate steps --- Develop labelled and label-quantitative peptide assays to support fidelity (misincorporation) and titer methods throughout the product development cycle --- Participate in comparability studies to establish product attribute profile and support process characterization and validation --- Collaborate with internal teams and external CMOs or CROs and provide support to different activities as needed --- Manage priorities, plan experiments, conduct analysis and report results to project teams --- Prepare research reports and presentations for team meetings, and draft laboratory standard operation procedures Education/Experience: --- Ph.D. in analytical chemistry or related disciplines with a minimum of10 years relevant industry experience --- Substantial scientific knowledge and hands-on experience in protein structure elucidation, identification and quantitation of related impurities or PTMs and degradants using LC-MS/MS --- Practical experience in protein or peptide quantitation by mass spectrometry using a label or label-free technologies --- Masters software and bioinformatic strategies for protein identification and quantitation --- Experience in in-vivo and ex-vivo PK/PD assays, metabolite identification, automation in high throughput LC/MS based assay is preferred --- Working knowledge of HDX-MS is a plus --- Ability to work with different LC-MS systems and software, performing routine maintenance and troubleshooting --- Programing using Visual Basic, PE Multiprobe HT or Tecan liquid handler is a plus --- Familiarity with ICH, USP and FDA requirements for method development validation --- Ability to work in a fast-paced and team-orientated environment, and commitment to a collaborative and professional work environment --- Excellent organization skills and ability to multi-task and manage priority --- Excellent computer skills: proficiency with Microsoft Excel and PowerPoint required --- Good oral and written communication skills a must At Sanofi diversity and inclusion is foundational to how we operate and embedded in our Core Values. We recognize to truly tap into the richness diversity brings we must lead with inclusion and have a workplace where those differences can thrive and be leveraged to empower the lives of our colleagues, patients and customers. We respect and celebrate the diversity of our people, their backgrounds and experiences and provide equal opportunity for all.

Keywords: Synthorx, Inc., San Diego , Principal Scientist, Analytical Development, Other , La Jolla, California

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