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Senior Research Associate/Associate Scientist - Immuno-Oncology

Company: TC Industries Of Canada Company
Location: San Diego
Posted on: September 16, 2020

Job Description:

Senior Research Associate/Associate Scientist - Immuno-Oncology

San Diego, CA • Preclinical

Poseida is seeking an outstanding candidate to join our Immuno-Oncology team. The Senior Research Associate or Associate Scientist will support the development chimeric antigen receptors (CAR-T) cellular therapies against cancer, and possibly other disease areas. Primary responsibilities will involve designing and performing experiments, organizing and sharing data, and the coordination of research projects in a highly collaborative team setting, with the assistance of your manager.

Responsibilities

These may include but are not limited to:

Support the development of CAR-T cellular therapies at the preclinical stage

Studies may include generation of genetically modified human T cells for product development and/or for understanding product biology

Employ and develop different cell-based and FACS-based techniques for in vitro characterization of cell therapy products

Participate in the design of in vivo studies and in the coordination of activities to support them

Support activities such as construct design, cloning, and testing next-generation cell engineering approaches

Present data (written and oral) in internal and cross-functional meetings, as required

Requirements Requirements, Knowledge, Skills and Abilities

BS with 8-plus years or MS with 5-plus years of experience in the field of immunology, molecular biology, or related field (an equivalent combination of education and experience may be considered)

Strong knowledge of diverse cell-based assays including cellular activation, cytokine release, proliferation assay and luciferase killing assay

Proficiency in multi-parameter flow cytometry and FACS data analysis via FlowJo

Molecular biology, Cloning and PCR technologies, nucleic acid production and purification

Prior experience in planning and execution in vivo xenograft models

Demonstrated track record in the characterization, culture, expansion, and manipulation of T cells or CAR-T is highly desired

Experienced in NGS assays and/ or genetic manipulation of T cells with CRISPR/Cas9 or other gene-editing systems is a plus

Experience with various cell separation technologies (e.g., Miltenyi CliniMACS) and FACS sorting is a plus

Proficiency with electroporation techniques and technologies (Plasmid DNA, IVT RNA) is a plus

Ability to organize, communicate, and present complex data sets to key stakeholders from diverse backgrounds

Excellent communicator with track record of working effectively as an individual contributor and in teams

Keywords: TC Industries Of Canada Company, San Diego , Senior Research Associate/Associate Scientist - Immuno-Oncology, Other , San Diego, California

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