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Vice President of Medicinal Chemistry

Company: Turning Point Therapeutics
Location: San Diego
Posted on: September 17, 2020

Job Description:

Turning Point Therapeutics is a clinical-stage precision oncology company with a pipeline of internally discovered investigational drugs designed to address key limitations of existing cancer therapies. The company’s lead program, repotrectinib, is a next-generation kinase inhibitor targeting genetic drivers of non-small cell lung cancer and advanced solid tumors. Turning Point Therapeutics is driven to develop therapies that mark a turning point for patients in their cancer treatment.

Turning Point Therapeutics is seeking a highly motivated and experienced leader for heading our medicinal chemistry efforts. This position is reported directly to CSO and is responsible for our overall medicinal chemistry strategies and approaches for small molecule drug discovery programs.

Role Responsibilities

Provide leadership to initiate and lead cutting edge small molecule drug discovery programs at Turning Point Therapeutics

Develop and execute research and medicinal chemistry strategies and approaches for fast progression of small molecule drug discovery projects

Ensure robust, cost-effective support of company discovery and development portfolio

Support the CSO in planning research and discovery activities including internal and external projects

Develop accurate budget and staff projections to support multidisciplinary team goals

Recruit high-quality chemistry personnel to support chemistry plan

Evaluate and select CROs and CMOs to support key preclinical chemistry activities

Oversee both internal chemistry team and external preclinical chemistry resources

Providing strong support and guidance to Turning Point’s intellectual property strategy and portfolios

Qualifications

PhD in organic/medicinal chemistry

Small molecule oncology experience required

15-20 years’ experience in the pharmaceutical industry with preclinical and clinical development activities

Broad knowledge in current synthetic methodology, ligand design as well as protein structure-based drug design, use of stereoelectronic interactions

Strong familiarity with physicochemical properties as they relate to drug design/development and application of ligand efficiency (LE) and lipid ligand efficiency (LLE) principles to design

Deep knowledge in drug discovery and development including the progression of compounds through the discovery cycle into pre-clinical and clinical development

Demonstrated a strong track record of success in advancing compounds to clinical candidate selection and beyond

Comprehensive medicinal chemistry knowledge from designing and identifying hits to clinical candidate selection

Thorough understanding of PK-ADME principles

Fast pace, attention to detail, and a passion for delivering important new therapies to patients with unmet medical needs

Outstanding scientific leadership, collaboration, and management skills

Proven track record of sustained high performance and innovative project contributions, including patents, presentations and/or peer-reviewed publications

Effective communication of hypotheses, SAR analysis, and structural designs/docking experiments using graphics tools and interactive sessions

Able to engage and influence senior leadership in strategic discussions.

Experience in young rapidly growing biotech companies

Turning Point Therapeutics is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Turning Point Therapeutics also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Turning Point Therapeutics is an E-Verify employer.

Keywords: Turning Point Therapeutics, San Diego , Vice President of Medicinal Chemistry, Other , San Diego, California

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