SanDiegoRecruiter Since 2001
the smart solution for San Diego jobs

Vice President of Medicinal Chemistry

Company: Turning Point Therapeutics
Location: San Diego
Posted on: September 17, 2020

Job Description:

Turning Point Therapeutics is a clinical-stage precision oncology company with a pipeline of internally discovered investigational drugs designed to address key limitations of existing cancer therapies. The company’s lead program, repotrectinib, is a next-generation kinase inhibitor targeting genetic drivers of non-small cell lung cancer and advanced solid tumors. Turning Point Therapeutics is driven to develop therapies that mark a turning point for patients in their cancer treatment.

Turning Point Therapeutics is seeking a highly motivated and experienced leader for heading our medicinal chemistry efforts. This position is reported directly to CSO and is responsible for our overall medicinal chemistry strategies and approaches for small molecule drug discovery programs.

Role Responsibilities

Provide leadership to initiate and lead cutting edge small molecule drug discovery programs at Turning Point Therapeutics

Develop and execute research and medicinal chemistry strategies and approaches for fast progression of small molecule drug discovery projects

Ensure robust, cost-effective support of company discovery and development portfolio

Support the CSO in planning research and discovery activities including internal and external projects

Develop accurate budget and staff projections to support multidisciplinary team goals

Recruit high-quality chemistry personnel to support chemistry plan

Evaluate and select CROs and CMOs to support key preclinical chemistry activities

Oversee both internal chemistry team and external preclinical chemistry resources

Providing strong support and guidance to Turning Point’s intellectual property strategy and portfolios


PhD in organic/medicinal chemistry

Small molecule oncology experience required

15-20 years’ experience in the pharmaceutical industry with preclinical and clinical development activities

Broad knowledge in current synthetic methodology, ligand design as well as protein structure-based drug design, use of stereoelectronic interactions

Strong familiarity with physicochemical properties as they relate to drug design/development and application of ligand efficiency (LE) and lipid ligand efficiency (LLE) principles to design

Deep knowledge in drug discovery and development including the progression of compounds through the discovery cycle into pre-clinical and clinical development

Demonstrated a strong track record of success in advancing compounds to clinical candidate selection and beyond

Comprehensive medicinal chemistry knowledge from designing and identifying hits to clinical candidate selection

Thorough understanding of PK-ADME principles

Fast pace, attention to detail, and a passion for delivering important new therapies to patients with unmet medical needs

Outstanding scientific leadership, collaboration, and management skills

Proven track record of sustained high performance and innovative project contributions, including patents, presentations and/or peer-reviewed publications

Effective communication of hypotheses, SAR analysis, and structural designs/docking experiments using graphics tools and interactive sessions

Able to engage and influence senior leadership in strategic discussions.

Experience in young rapidly growing biotech companies

Turning Point Therapeutics is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Turning Point Therapeutics also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Turning Point Therapeutics is an E-Verify employer.

Keywords: Turning Point Therapeutics, San Diego , Vice President of Medicinal Chemistry, Other , San Diego, California

Click here to apply!

Didn't find what you're looking for? Search again!

I'm looking for
in category

Other Other Jobs

Pallet Wrapper
Description: We're hiring hard-working pallet wrappers to be a part of a great team at a large logistics company br Responsibilities: br br li Place and layer
Company: Bluecrew
Location: Placentia
Posted on: 09/20/2020

Checker / Cajero(a) El Super - Paramount, CA (Paramount, CA)
Description: Under direct supervision of the Front End Supervisor, the Cashier is responsible for maintaining outstanding customer service as per company standards, processing sales quickly, accurately and efficiently, (more...)
Company: El Super
Location: Paramount
Posted on: 09/20/2020

Lot Associate
Description: Job DescriptionLot Associates assist customers with the loading of their vehicles and also monitor
Company: Home Depot
Location: Santee
Posted on: 09/20/2020

Lead System Engineer
Description: Would you like to be part of the new space movement Are you a rock star engineer Do you have the leadership gene Raytheon Intelligence Space is the place for you. In the last few years you might (more...)
Company: RTX
Location: La Mirada
Posted on: 09/20/2020

Full-time Amazon Package Sorter Bonus + Benefits Your First Day (Rialto)
Description: Job Description: 10 10 Warehouse Team Member - Bonus Full-Time Shifts: Overnight, Day, Evening, Weekend Location Rialto Job opportunities vary by location. We update postings daily with open positions. (more...)
Company: Amazon Workforce Staffing
Location: Yucaipa
Posted on: 09/20/2020

Customer Service/Sales
Description: Customer Service/Sales 303197069 Lake Elsinore, California, US, 92531 Position Purpose: Customer Service/Sales associates provide fast, friendly service by actively seeking out customers to assess their (more...)
Company: The Home Depot
Location: Lake Elsinore
Posted on: 09/20/2020

Amazon Warehouse Worker - Immediate Hire with Benefits
Description: Warehouse Team Member Seasonal, Part-Time, Full-Time, Flexible Hours Shifts: Overnight, Day, Evening, Weekend Location Chino and Eastvale Job opportunities vary by location. We update postings daily (more...)
Company: Amazon Workforce Staffing
Location: La Mirada
Posted on: 09/20/2020

Seasonal Amazon Package Sorter Up to $500 sign on bonus (Rialto)
Description: Warehouse Team Member - Bonus Seasonal, Part-Time, Full-Time, Flexible Hours br br Shifts: br Overnight, Sunrise, Day, Evening, Weekend br br Location br Rialto br Job opportunities vary (more...)
Company: Amazon Workforce Staffing
Location: Yucaipa
Posted on: 09/20/2020

Security Officer - Part Time All Shifts Available
Description: Job DescriptionJOB SNAPSHOT br br GardaWorld Security Services is currently hiring Security officers are considered to be essential services helping keep everything together during this time. Be (more...)
Company: GardaWorld
Location: La Mirada
Posted on: 09/20/2020

Strategic Account Executive (SAE)
Description: Join this 20 year innovative commercial services company as the next San Diego Sales Representative. This opening is open due to expansion This role is an Outside Sales Representative role in selling (more...)
Company: Culver Careers
Location: Poway
Posted on: 09/20/2020

Log In or Create An Account

Get the latest California jobs by following @recnetCA on Twitter!

San Diego RSS job feeds