Research Associate II- Protein Science/Molecular Biology

Company: AlivaMab Discovery Services
Location: San Diego
Posted on: February 23, 2021

Job Description:

US-CA-San DiegoID: 2020-1387Category: Research & DevelopmentOverview

AlivaMab Discovery Services ("ADS") seeks an outstanding individual with a range of skill sets in antibody purification, analytics, and recombinant protein expression for the position of Research Associate II - Protein Science / Molecular Biology located in San Diego. This candidate should be a motivated team player, able to handle multiple projects while working in an exciting, fast-paced environment, to discover the next generation of breakthrough antibody drugs. The Research Associate II - Protein Science / Molecular Biology will report to the Associate Director of Protein Sciences and work closely with the Antibody Discovery team.

ADS combines deep expertise and innovative technologies for the rapid discovery and development of superior antibody therapeutics. The company has developed a highly optimized fully-integrated antibody therapeutic discovery and development platform that leverages the AlivaMab Mouse technology and the ADS team's expertise to deliver diverse panels of highly characterized fully human antibody leads in unparalleled timelines. We seek talented, experienced, and enthusiastic people to join our team as we build a premier organization to meet and exceed the expectations of partners conducting antibody therapeutic discovery and development. The successful applicant will be a key contributor in a fast-growing team dedicated to delivering superior therapeutic antibody candidates that will improve outcomes for patients.

Responsibilities

Key Responsibilities:

• Antibody purification and analytics (antibody purification based on protein A and ion exchange and antibody characterization via SDS-PAGE and SEC-HPLC
  • Transient expression of antibodies using CHO based expression
    • Assist with molecular biology workflows
    • Executing and delivering for projects and preparing written reports
      • Organization of day to day experiments and timely updating of experimental files
        • Experimental design, experiment execution and troubleshooting
          
          Qualifications
          
          Qualifications:
          
          • BS/MS in biology, biochemistry, immunology and familiar with antibody therapeutic discovery and development
          • At least 3 years of relevant industry experience
          • Strong knowledge and skill in protein purification and analytics, specifically antibodies and various antibody formats
          • Extensive experience using Protein A and ion exchange methods for antibody purification
            • Experience with purification instrumentation such as Akta or similar
              • Experience with SDS-PAGE and SEC-HPLC for antibody analysis
              • Experience with molecular biology techniques (PCR, DNA/RNA isolation, plasmid prep, gel extraction, cloning, Sanger sequence analysis)
                • Ability to multi-task and history of timeline-driven delivery
                  • Excellent trouble shooting and problem-solving capabilities
                  • Extraordinary attention to detail, planning, and organizational skills
                  • Outstanding oral and written communication skills
                    • Experience with antibody engineering and reformatting, high-throughput recombinant expression, NGS, therapeutic antibody developability assessments, and experience in performing and optimizing transient transfections of antibodies utilizing CHO based suspension systems is preferred
                      
                      The successful applicant should be prepared to work in a high-energy, goal- and timeline-driven environment. Good internal and external collaborative abilities are required, including excellent listening and creative problem solving. The successful applicant will be high functioning in an environment dedicated to exceptional quality and integrity. Excellent communication skills and being able to present in front of external audiences is required. Proficiency in Microsoft Office and instrument specific software (Agilent Open Lab, GE Unicorn) is required.
                      
                      AlivaMab Discovery Services is a privately held technology company with a highly optimized fully-integrated antibody therapeutic discovery and development platform that combines deep expertise and innovative technologies for the rapid discovery and development of superior antibody therapeutics in unparalleled timelines. The team has executed over 200 discovery projects that have yielded several dozen antibody drug candidates in clinical trials. ADS delivers diverse panels of high affinity antibody therapeutic candidates, with extensive molecular and epitope diversities, functional and kinetic characterization, and superior developability profiles. The integrated platform leverages proprietary technologies and spans from collaboratively designing the discovery plan to generation of immunogens, development of functional screening assays, to delivery of fully human therapeutic antibodies that have been optimized for developability.
                      
                      AlivaMab Discovery Services provides equal employment opportunities (EEO) to all employees and applicants for employment without regard to religion, race, creed, color, sex, sexual orientation, alienage or citizenship status, national origin, age, marital status, pregnancy, disability, veteran or military status, predisposing genetic characteristics or any other characteristic protected by applicable federal, state or local law.
                      
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Keywords: AlivaMab Discovery Services, San Diego , Research Associate II- Protein Science/Molecular Biology, Other , San Diego, California