Scientist (non-PhD), Immunotherapeutic Design
Location: La Jolla
Posted on: June 13, 2021
The Cancer Immunology Discovery (CID) group in La Jolla, CA is
focused on the generation of large molecule immunotherapeutics that
promote anti-tumor activity or counter immunosuppression in the
tumor microenvironment. Protein engineering efforts are supported
by a world class antibody generation program, and a commitment to
effective biotherapeutic design that stresses both ingenuity and
simplicity. Our team takes a holistic approach to understanding the
interplay of tumor, stromal, and immune cells in the tumor
microenvironment, striving to define the axes of intercellular
communication that could be leveraged to generate novel
We are seeking a qualified candidate to join us at a BS/MS
Scientist level to contribute to protein engineering activities for
the identification of novel biotherapeutics. The successful
candidate will be responsible for expression, purification, and
characterization of proteins from diverse formats including fusion
proteins, antibodies, and bi-/multi-specific antibodies.
The successful candidate will demonstrate clear and professional
verbal and written communication, maintain an electronic notebook,
and present scientific results to collaborators and at team
meetings. This position will not have any direct reports. There
will be less than 5% travel.
Production of therapeutic antibodies and other biologics,
including plasmid design, cloning, giga scale purification,
transient transfection, protein expression and harvesting.
Support protein purification efforts using multiple
Assess yield, purity, and other biophysical parameters like
analytical characterization of proteins using state-of-the-art
techniques and instrumentation.
- Help to build a culture that embraces scientific excellence,
continuous learning, and increasing the team's ability to deliver
novel drug development opportunities through the rapid
incorporation of emerging biotechnologies to ensure our team
continues research on the leading-edge of oncology drug
BS/MS in Biochemistry, Molecular Biology, or related
5+ years of laboratory experience.
Technical expertise should include protein expression,
purification, biophysical and biochemical characterization.
Strong understanding of molecular biology and protein
Motivated, proactive, and eager to learn.
Excellent communication and presentation skills.
- Experience maintaining cell-lines and performing
Previous industrial experience is strongly preferred.
Experience with mammalian protein expression system is strongly
Advanced molecular design proficiency.
- Hands-on experience with instruments such as GE AKTA
Pure/Avant, Agilent HPLC, Perkin-Elmer LabChip, and Uncle.
Lifting, sitting, standing, walking, bending, ability to perform
mathematical calculations and ability to perform complex data
- Must be able to wear PPE (lab coat/safety
NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT
- Must be willing and able to work after hours as needed to
ensure study integrity
OTHER JOB DETAILS
- Eligible for Employee Referral Bonus
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have questions regarding this matter, please do not hesitate to
contact your Talent Acquisition representative.
EEO & Employment Eligibility
Pfizer is committed to equal opportunity in the terms and
conditions of employment for all employees and job applicants
without regard to race, color, religion, sex, sexual orientation,
age, gender identity or gender expression, national origin,
disability or veteran status. Pfizer also complies with all
applicable national, state and local laws governing
nondiscrimination in employment as well as work authorization and
employment eligibility verification requirements of the Immigration
and Nationality Act and IRCA. Pfizer is an E-Verify employer.
Research and Development
Keywords: Pfizer, San Diego , Scientist (non-PhD), Immunotherapeutic Design, Other , La Jolla, California
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