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Senior Scientist - Core Antisense Research

Company: Ionis Pharmaceuticals
Location: Carlsbad
Posted on: June 13, 2021

Job Description:

Ionis Pharmaceuticals, Inc., one of the 2020 Best Places to Work in San Diego, is located in the North San Diego County city of Carlsbad. Ionis was founded in 1989 and was purposely designed to create a better, more efficient drug discovery platform, establish a new innovation-centered business model, and maximize the value of every medicine created and get it to the people who need it most as quickly and as efficiently as possible.

With the RNA molecule as the basis of our novel drug discovery platform, we are targeting an unprecedented range of therapeutic areas. Our antisense therapies are disrupting diseases and changing their course-from the rarest of conditions, to those that impact millions of people. We currently have three commercial products and more than 40 potentially transformative medicines in our pipeline designed to treat a broad range of diseases.

Ionis is a challenging, motivating and rewarding environment designed to foster innovation and scientific excellence. Our success is a direct result of our outstanding employees. We are interested in bringing together individuals with different skill sets into this creative environment to be part of a productive team. Join us and experience our unique culture while you develop and expand your career.

SENIOR SCIENTIST - CORE ANTISENSE RESEARCH

The selected candidate will work with a multi-disciplinary team of energetic researchers who are focused on unraveling the complex mechanisms underlying antisense oligonucleotide (ASO) drugs. The emphasis will be to understand mechanisms of ASO action in cells and intracellular trafficking pathways of ASOs.

REQUIREMENTS:

  • A Ph.D. in Cell Biology, Molecular Biology, or related field.
  • At least 2 years of post-doctoral research experience.
  • Broad knowledge and experimental experience with nucleic acid-protein interactions, RNA biology, intracellular trafficking, membrane and cytoskeleton are desired.
  • Track record of innovative research and scientific publications in the related field.
  • Skills/experience in RNA biology, protein complex purification, confocal imaging, and antisense technology are highly preferred.
  • Excellent organizational, interpersonal and oral communication skills.
  • An ability to work both independently and as a team member, and be productive and successful in an intense work environment.

RESPONSIBILITIES:

  • Responsible for investigating how ASO drugs work in cells, with a goal to improve the drug design and to expend antisense technology.
  • Specifically studies how ASO drugs enter and traffic in cells, endosomal release, the intracellular action sites of ASOs, interactions of ASOs with cellular proteins and RNAs, and the consequences of such interactions on the performance of the ASO drugs and biological processes.
  • Develop approaches to enhance endosomal release of ASOs.
  • Emphasis on understanding the mechanisms of ASO-directed, RNase H cleavage of target RNAs.
  • Develop new antisense mechanisms to modulate gene expression with clinical application.
  • Investigates the structure-activity relationships of ASO/protein, ASO/RNA, and RNA/protein interactions on the performance of ASOs.
  • Works with a multi-disciplinary team of energetic researchers who are focused on unraveling the complex mechanisms underlying antisense drugs.
  • Conducts studies to understand the mechanisms of how antisense drugs work in cells using different techniques including but not limited to cell culture and treatment, small animal handling, DNA/Protein and essentially RNA manipulation, oligonucleotide/Protein and protein-protein interactions, gene expression manipulation, structure-activity relationship study, subcellular localization and trafficking analysis using both biochemistry and cell biology approaches.
  • Present and publish research data.

Excellent salary and benefits package offered.

For more information about Ionis and to apply for this position, please visit our website, www.ionispharma.com. Reference Requisition #IONIS02523

NO PHONE CALLS PLEASE. PRINCIPALS ONLY.

Ionis Pharmaceuticals, Inc. and all its subsidiaries are proud to be EEO employers.

Keywords: Ionis Pharmaceuticals, San Diego , Senior Scientist - Core Antisense Research, Other , Carlsbad, California

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