Location: San Diego
Posted on: November 22, 2021
POSITION: Associate Scientist/Scientist, Discovery Biology
We are seeking a highly motivated Associate Scientist/Scientist
with strong background in tumor biology to join us in
identification and characterization of Client therapeutics for the
treatment of hematological cancer. The successful candidate will
work collaboratively in a multi-disciplinary environment to Client
Client drugs and to understand their molecular mechanism of action.
Responsibilities include profiling of Client compounds in
cell-based assays to drive chemical SAR for lead research programs,
development of cellular assays to support target validation and
mechanism of action studies. In addition, support for lab
operations will include assistance in maintaining the liquid
nitrogen cell database and site compliance. The successful
candidate will work closely with discovery and development project
teams and scientists across the Oncogenesis functional areas.
Extensive experience designing, implementing and analyzing compound
effect using multiple platforms (multi-parameter flow cytometry,
Incucyte, Western blot, ELISA/MSD and functional assays such as
cytotoxicity, cell cycle and apoptosis) in the context of drug
discovery is desired.
Hands-on experience in mammalian cell culture (primary cells and
cell lines) is required while using genetic manipulation techniques
such as transfection, CRISPR RNP nucleofection and/or lentiviral
transduction is a plus.
Experience with HTS screening and the use of automation instruments
Flexibility and interest in learning new techniques and skills in
accordance with the research program needs.
Proficiency in scientific and data analysis programs including
Microsoft Excel, PowerPoint and GraphPad Prism is a must.
Ability to work in a fast-paced dynamic team environment;
flexibility to adapt to changes with a positive attitude and
independently collaborate across teams, requiring excellent
communication skills, both written and verbal, with strong
Ph.D. level in cell biology, immunology, molecular biology or
equivalent field with 0-3 years of experience, or M.S. degree with
a minimum of 4-6 years of experience or BSc with a minimum of 6-8
years of experience in biopharmaceutical industry developing and
optimizing cell-based assays. The position level will be dependent
Keywords: Eclaro, San Diego , Research Scientist, Other , San Diego, California
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