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Research Scientist

Company: Eclaro
Location: San Diego
Posted on: November 22, 2021

Job Description:

POSITION: Associate Scientist/Scientist, Discovery Biology
DEPARTMENT: Oncogenesis

Position Summary:
We are seeking a highly motivated Associate Scientist/Scientist with strong background in tumor biology to join us in identification and characterization of Client therapeutics for the treatment of hematological cancer. The successful candidate will work collaboratively in a multi-disciplinary environment to Client Client drugs and to understand their molecular mechanism of action. Responsibilities include profiling of Client compounds in cell-based assays to drive chemical SAR for lead research programs, development of cellular assays to support target validation and mechanism of action studies. In addition, support for lab operations will include assistance in maintaining the liquid nitrogen cell database and site compliance. The successful candidate will work closely with discovery and development project teams and scientists across the Oncogenesis functional areas.

Skills/Knowledge Required:
Extensive experience designing, implementing and analyzing compound effect using multiple platforms (multi-parameter flow cytometry, Incucyte, Western blot, ELISA/MSD and functional assays such as cytotoxicity, cell cycle and apoptosis) in the context of drug discovery is desired.
Hands-on experience in mammalian cell culture (primary cells and cell lines) is required while using genetic manipulation techniques such as transfection, CRISPR RNP nucleofection and/or lentiviral transduction is a plus.
Experience with HTS screening and the use of automation instruments is desired.
Flexibility and interest in learning new techniques and skills in accordance with the research program needs.
Proficiency in scientific and data analysis programs including Microsoft Excel, PowerPoint and GraphPad Prism is a must.
Ability to work in a fast-paced dynamic team environment; flexibility to adapt to changes with a positive attitude and independently collaborate across teams, requiring excellent communication skills, both written and verbal, with strong interpersonal skills.

PREREQUISITES:
Ph.D. level in cell biology, immunology, molecular biology or equivalent field with 0-3 years of experience, or M.S. degree with a minimum of 4-6 years of experience or BSc with a minimum of 6-8 years of experience in biopharmaceutical industry developing and optimizing cell-based assays. The position level will be dependent on experience.

Keywords: Eclaro, San Diego , Research Scientist, Other , San Diego, California

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