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Scientist III, In Vivo Delivery and Formulation R&D

Company: thermo fisher scientific
Location: Carlsbad
Posted on: November 23, 2021

Job Description:

Thermo Fisher Scientific Inc. is the world leader in serving science, with annual revenue exceeding $25 billion. Our Mission is to enable our customers to make the world healthier, cleaner and safer. Whether our customers are accelerating life sciences research, solving complex analytical challenges, improving patient diagnostics and therapies or increasing productivity in their laboratories, we are here to support them. Location/Division Specific Information: Carlsbad, CA Biosciences Division How will you make an impact? Contribute to the creation of the therapies of tomorrow. Our team is looking for an enthusiastic scientist to join our in vivo RNA delivery program. This scientist will participate in development of novel lipid nanoparticle (LNP) formulations that can allow our customers to develop RNA-based therapeutics. The successful candidate will have a strong background in formulation, experience in molecular biology, and will be proficient in animal work. The scientist will be a part of a highly collaborative team environment, and will work in close interaction with our internal partners around the globe. This position requires excellent communication and presentation skills, strong work ethic, independence and enthusiasm. What will you do? In vivo studies in mice Formulation of delivery vehicles Physicochemical characterization of LNPs Cell culture of primary cells and cell lines Genomic editing in vitro and in vivo Flow cytometry and cell sorting, qRT-PCR and immunofluorescence analyses, ELISA Design experiments, analyze data, and present the data to internal and external collaborators Work in collaboration with our colleagues in cell biology, chemistry and manufacturing departments to ensure smooth flow of information and data Execute the plans according to agreed timelines How will you get here? Education/Experience: PhD degree in life sciences (Pharmaceutical Sciences/ Biochemical Engineering/ Biomedical engineering/ Chemistry/ Biology) Strong background in formulation. The candidate must have a strong track record and experience in non-viral gene and/or RNAi delivery. Specifically, in depth knowledge and exposure to LNP-based gene delivery systems is desired. Expertize in LNP characterization Prior experience with in vivo delivery Adept in mouse handling, organ harvesting and primary cell isolation and analyses Preferred qualifications: Expertise in multicolor flow cytometry and cell sorting, fluorescent and confocal microscopy. Familiar with ELISA, ELISpot, cytokine arrays Experience in cancer immunology Background in cancer vaccine development is highly desired Prior experience in gene editing (CRISPR, TALEN, zink finger) Experience in transfection and transduction of primary cells Knowledge of JMP software and design of experiments Knowledge, Skills, Abilities: Excellent communication skills proven by publications and presentations Ability to work in collaborative environment and to be an effective team member Ability to independently troubleshoot Design, plan and execute experiments independently Maintain detailed records of experiments Our global team of more than 90,000 colleagues delivers an unrivaled combination of innovative technologies, purchasing convenience and pharmaceutical services through our industry-leading brands, including Thermo Scientific, Applied Biosystems, Invitrogen, Fisher Scientific, Unity Lab Services and Patheon. For more information, please visit Thermo Fisher Scientific is an EEO/Affirmative Action Employer and does not discriminate on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability or any other legally protected status. by Jobble

Keywords: thermo fisher scientific, San Diego , Scientist III, In Vivo Delivery and Formulation R&D, Other , Carlsbad, California

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