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Associate Scientist/Sr. Associate Scientist

Company: BioTheryX, Inc.
Location: San Diego
Posted on: January 15, 2022

Job Description:

BioTheryX is a privately held, clinical-stage biotech that is committed to transforming the treatment of cancer and immune disorders through the development of novel therapies that modulate disease-causing proteins.
Our principal technology platform centers on the development of targeted protein degraders, including PHM ----'molecular glues' and PHM-derived PROTACs, that hijack the cell's intrinsic protein disposal system - the ubiquitin-proteasome system - to selectively degrade disease-causing proteins. Including protein targets previously considered "undruggable." Drug development in the area of targeted protein degradation holds extraordinary promise in a broad range of therapeutic indications.
BioTheryX was founded by the chief architect behind one of the most successful classes of anti-cancer drugs globally, the IMiD franchise of compounds launched at Celgene. To date, IMiDs are the only class of approved drugs that selectively target cellular proteins for ubiquitin-mediated degradation. The identification of Cereblon, an E3 ubiquitin ligase, as the key IMiD-binding protein, clinically validated targeted protein degradation as a viable drug development strategy, which could provide significant therapeutic benefits and enormous commercial success.

  • We are seeking a highly- motivated scientist to join our drug discovery group. The successful candidate will join a group of dynamic researchers to evaluate the effects of novel compounds in in vitro cancer and immunology models. The candidate must have extensive experience with mammalian tissue culture, routine cell-based assays, assay development, and performing high-throughput screening for our compound library. The candidate will be a strong team player and will need to complete assigned projects independently and in a timely manner.
    • B.Sc. with a minimum of 8-10 years of hands-on laboratory experience in an academic or industry setting
    • M.Sc. with about 4-5 years of hands-on laboratory experience in an academic or industry setting
      Key Technical Skills:
      • Strong hands-on experience with mammalian cell culture, cell lines, and primary cells
      • Establishing stable/drug-resistant cell lines
      • Experience in small molecule libraries
      • Genetic manipulation using CRISPRs, TALENs, or ZFNs
      • Viral vector design and transduction techniques (retroviral, lentiviral)
      • High-throughput cell viability assays
      • Western blots, immunoprecipitation, qPCR
      • Immunoassays, ELISA
      • Multi-color Flow cytometry
      • Fluorescent microscopy
      • Strong analytical skills; ability to analyze and troubleshoot with minimal guidance
      • Strong oral and written communication skills; proven ability to summarize and present scientific findings in a professional manner
      • Ability to work and meet deadlines
      • Proficient in Word, Excel, and Powerpoint
        Performance Expectation:
        • Maintenance of cell lines and primary cells, cryopreservation
        • Perform routine high-throughput cell viability assays to evaluate compound efficacy, run western blot analysis
        • Cell-based assay development
        • Generating gene knock-down, knock-out and knock-in cell lines
        • Ability to understand and implement concepts of oncology and immunology
        • Maintain an accurate and complete laboratory notebook, excellent record-keeping
        • Deliver results in a multidisciplinary team environment that includes collaborations with top research laboratories and institutes
        • Ability to organize, communicate, and present complex data sets to key stakeholders from diverse backgrounds
          What BioTheryX Offers:Competitive SalaryPaid Time Off (PTO) PlanPPO Medical PlanDental and Vision PlansBasic Life Insurance and AD&D Insurance at no cost to the employee401k PlanEmployee Assistance Program (EAP)
          Equal Employment Opportunity
          • BioTheryX, Inc. provides equal employment opportunities (EEO) to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, gender identity or expression, national origin, age, disability, genetic information, marital status, amnesty, or status as a covered veteran in accordance with applicable federal, state and local laws.

Keywords: BioTheryX, Inc., San Diego , Associate Scientist/Sr. Associate Scientist, Other , San Diego, California

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