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Senior Scientist (Oligonucleotide)

Company: StaffWorks, LLC
Location: San Diego
Posted on: January 16, 2022

Job Description:

Our client is looking for an individual to aid in the development and validation of novel chemical construction techniques for the optimization of oligonucleotide therapeutics. The individual must thrive in an independent, fast paced, and constantly evolving environment. An ideal candidate will be a "jack of all trades" and be able to tackle any oligonucleotide chemistry problem we might have.
Our ideal candidate will bring a wide breadth of experience from solid phase synthesis (SPOS) to the experimentation with synthesized biopolymers. In this role, you will work closely with other teams to design and optimize sequence and chemistry of next gen oligonucleotide drugs. Experience in oligonucleotide chemistry and RNAi biology is a plus.
Responsibilities

  • Design and optimize sequence and chemistry of next gen oligonucleotide drugs
  • Responsible for operating/maintaining an automated oligo synthesizer
  • Optimize and troubleshoot SPOS protocols using novel chemistries
  • Document experiments and results in a regulatory compliant manner
  • Effectively communicate results, ideas and strategies in presentations and written reports
  • Assist to hire, train and mentor research staff as needed
  • Work across all functional groups to meet timelines and facilitate development
  • Maintain scientific knowledge and critically evaluate scientific literature and industry trends in order to contribute to research efforts
  • Write abstracts and present posters at scientific meetings
  • Work on and contribute to other projects as needed and assigned
    Requirements
    • Ph. D. in Chemistry, Chemical Biology, or Biochemistry
    • RNAi chemistry
    • Solid phase oligonucleotide synthesis (SPOS)
    • Post SPOS cleavage and desalting of oligonucleotides
    • Wet lab chemistry techniques
    • HPLCMS analysis of oligonucleotides
    • Synthesis of nucleoside monomers
    • Analysis of oligonucleotides in biochemical assays
    • Familiarity with chemically modified oligonucleotides
    • Basic biochemical manipulations, screening, and selections
    • Ability to work with a sense of urgency and positive, can-do approach
    • Familiarity with basic NGS, theory and library preparation techniques

Keywords: StaffWorks, LLC, San Diego , Senior Scientist (Oligonucleotide), Other , San Diego, California

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