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Senior Scientist

Company: BioPhase
Location: San Diego
Posted on: January 16, 2022

Job Description:

Senior Scientist-Process Development
Up to 160K with bonus & equity
Position SummaryThis role will be responsible for designing and implementing new cell therapy processing methods to expand the ability to manufacture novel cell therapies effectively in large scale. The ideal candidate will have a proven track record of successfully developing new cell processing methods, working closely with a multidisciplinary team of scientists and engineers. They will be a technical leader in the field of cell selection, conditioning, and culture, designing multi-experiment approaches to solve complex problems, coordinating day-to-day team efforts, and mentoring junior scientists and engineers to increase R&D capabilities and knowledge.
Job Responsibilities

  • Oversee complete experimental plans and technical roadmaps to enable new cell therapy modalities, including but not limited to CAR-T, NK, TIL, HSC and B cell workflows.
  • Drive innovation through development of novel cell processing hardware and workflows to manufacture autologous cell therapies.
  • Perform process characterization, optimization, and comparability studies, as required.
  • Assist in developing, executing, and troubleshooting new cell engineering approaches (CRISPR, prime editing, base editing, mRNA) and analytical methods (Cytof, ddPCR, sequencing).
  • Prepare and follow standard operating procedures, batch records, and other process documentation.
  • Analyze and document experimental data in electronic laboratory notebooks in a timely and accurate manner in accordance with the company quality management system.
  • Mentor scientists and research associates in proper laboratory techniques and scientific experimental design.
  • Attend and present scientific data to colleagues at internal and external meetings.
  • Participate in daily Agile stand-ups and weekly sprints with other members of the research team.
    • PhD degree in Biology, Engineering, Medicine or related discipline with 8+ years of laboratory research or industry experience.
    • 3+ years of expertise in cell processing hardware and processes.
    • Subject-matter expert in the area(s) of T-cell, HSC, B, or other specific cell therapy modality.
    • Extensive hands-on experience in with commercial cell processing systems
    • Familiarity with new cell editing technologies and advanced cell therapy analytical methods.
    • Demonstrated independent problem solving and systematic data-driven experimental design and execution.
    • Demonstrated ability to clearly communicate technical information and roadmaps through written protocols and/or presentations containing clean figures and visualizations.
    • Innovative and analytical thinker with outstanding interpersonal, communication, and leadership skill.
    • Must be highly disciplined and organized, self-motivated and enthusiastic about taking a hands-on approach to collaborative scientific discovery efforts.
      Preferred Experience
      • Expertise in CRISPR and vector design and related annotation tools
      • Expertise in designing PCR and NGS assays for genome engineering
      • Statistical analysis of genotypic, gene expression data in bulk and single cell samples
      • Knowledge of viral vector design (AAV, Lentivirus, Gamma retrovirus) and vector manufacturing processes.
      • Experience in setting up and working within a GxP environment
      • Exposure to pre-clinical R&D and IND filing requirements for a cell and gene therapy products
      • Experience in interfacing with laboratory automation (e.g. automated liquid handlers) and data analysis software.
      • Experience with coding and running bioinformatics scripts (Python, numpy, scipy, pandas, jupyter).

Keywords: BioPhase, San Diego , Senior Scientist, Other , San Diego, California

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