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Principal Scientist, Medicinal Chemistry

Company: Vividion Therapeutics. Inc.
Location: San Diego
Posted on: January 16, 2022

Job Description:

Company Overview:

Vividion is a next generation biotechnology company based in San Diego that is leveraging its proprietary chemical proteomics platform to conduct proteome-wide footprinting of small molecule-protein interactions with unprecedented breadth and precision. Our technology allows us to screen, identify and optimize novel drugs that selectively bind virtually any protein, including those previously considered "undruggable". Our pipeline and emerging programs reflect a matured and productive platform capable of delivering first-in-class drugs utilizing novel mechanisms of action (allosteric inhibitors, protein-protein interaction inhibitors, functional activators, degraders, etc.) against undruggable targets in the oncology and immunology space.

Job Summary:

As a senior member of the Vividion chemistry department, the successful candidate will be able to contribute to all priority phases of the drug discovery process including library growth, hit identification, hit to lead, and guide lead optimization programs to successful Development Candidate nominations and IND submissions. The preferred candidate will be comfortable balancing the use of traditional approaches, exploring novelty on the cutting edge of modern small molecule drug discovery, and have a thirst to constantly learn.

Education and Experience requirements:

  • PhD +/- post doctoral experience in synthetic organic chemistry
  • 7+ years of industry experience in small molecule drug discovery with a clear understanding of program strategy, therapeutic hypothesis, assay relevance and clinical translation, and the importance of physical-chemical properties as they relate to enabling late-stage in vivo studies and clinical dosing
  • A clear command of classical and modern synthetic methodology and reaction mechanism
  • Expertise to craft compounds that fully exploit insights from ligand and/or structure-based design while fully exploiting all available synthetic methods
  • Proven leadership skills within and across multiple functions as part of integrated drug discovery teams as exemplified by delivery of development candidate small molecules
  • Experience in mentoring and managing both internal junior chemists and outsourced chemistry resources
  • Excitement and unhesitating commitment to advance a rapidly growing biotech organization in any way necessary including from the lab as needed

    Required Key Attributes:
    • Curiosity
    • Fearlessness
    • Creativity
    • Attention to detail
    • Willingness to challenge dogma

      Further Information:

      In addition to a competitive compensation package, Vividion also offers a comprehensive benefits package for our employees and their families, which includes medical, dental, vision, life, and disability insurance.

      Vividion Therapeutics, Inc. is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.

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      The protection of your personal information is a commitment we take seriously. For information regarding our Privacy Policy (CA candidates) please see

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Keywords: Vividion Therapeutics. Inc., San Diego , Principal Scientist, Medicinal Chemistry, Other , San Diego, California

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