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Senior Scientist, Bioanalytical & DMPK

Company: DTx Pharma
Location: San Diego
Posted on: January 16, 2022

Job Description:

DTx Pharma is seeking an enthusiastic and highly motivated individual to support research and preclinical activities. The successful candidate will be a member of the bioanalytical and drug metabolism and pharmacokinetics (DMPK) team which develops bioanalytical assays for oligonucleotide quantification and metabolite profiling, conducts studies to understand the uptake of oligonucleotides into biological matrices and their metabolism, facilitates projects at CROs for method development, method qualification/validation, method transfer, and bioanalytical analysis. This position operates within a fast-paced interdisciplinary environment, so good communication, flexibility and being -organized and detailed-oriented -are required. The successful candidate will be responsible for:

  • Developing and optimizing bioanalytical assays to analyze oligonucleotides in biological matrices -
  • Performing experimental design, implementing experiments, data analysis and summary, reporting results, and providing proposals on follow-up experiments
  • Overseeing bioanalytical lab activities including reagents preparation, stocking of supplies, sample processing, equipment operation and maintenance
  • Corroborating accurate and complete records of all bioanalytical experiments and ensuring that these records and raw data are properly retained
  • Contributing to development of internal SOPs
  • Assisting bioanalytical activities with external providers and development partners
  • Assisting purchase and installation of new equipment and instrumentation
  • Working collaboratively with other members of the chemistry and biology teams
  • Effective presentation at internal meetings as well as clear written and verbal communicationQualifications & Experience:
    • Master's degree in Biochemistry, Analytical Chemistry, or Pharmaceutics and Pharmacology with at least 6 years of industry experience, or Ph.D. degree in Biochemistry, Analytical Chemistry, or Pharmaceutics and Pharmacology with at least 3 years of industry experience
    • Solid experience in initiating and managing projects and studies
    • Track record of developing, optimizing, and performing HELISA, LCMS, or LCFD based quantitative assay
    • Proficient in data analysis for quantitative and qualitative workflows by using vendor's software or publicly available software
    • 3 years of hands-on experience with biological sample preparation like tissue homogenization, sample digestion, liquid-liquid or solid-phase extraction. Previous experience with oligonucleotide extraction from plasma and tissue samples is preferred.
    • Previous experience with authoring study plans, protocols, and reports
    • Previous experience with DMPK concepts and PK data interpretation.
    • Strong organizational and time-management skills, ability to multitask, prioritize, work within schedules and deadline.
    • Excellent written and verbal communication skills
    • Ability to work as a team player as well as to think critically and work independentlyCompany Overview:DTx Pharma, Inc. is a privately-held biotechnology company based in San Diego, CA creating novel RNA-based therapeutics to treat the genetic drivers of disease. The company's proprietary delivery technology platform utilizes fatty acids as targeting ligands to enable the delivery of oligonucleotide therapies to tissues and cell types throughout the body. In preclinical studies, DTx has demonstrated cellular uptake and broad activity of oligonucleotides in the retina, muscle, heart, neurons, T cells, and other specialized cell types. To advance the FALCON platform toward and into clinical development, DTx has raised more than $100M in combined investment from several of the world's leading healthcare investors including RA Capital Management and Access Biotechnology, pharmaceutical companies such as Eli Lilly and Company, the National Institute of Health (NIH), and research foundations such as the CMT Research Foundation (CMTRF). To learn more about DTx Pharma, -please visit -www.dtxpharma.com -and follow DTx on LinkedIn and Twitter @DTxPharma.

Keywords: DTx Pharma, San Diego , Senior Scientist, Bioanalytical & DMPK, Other , San Diego, California

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