Senior Scientist
Company: AmpersandPeople
Location: San Diego
Posted on: May 16, 2022
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Job Description:
Job DescriptionSENIOR SCIENTIST: Pre-clinical drug discovery in
inflammatory disease at Orphagen PharmaceuticalsOrphagen
Pharmaceuticals is seeking an exceptional PhD level biologist, with
a strong background in drug discovery, immunology and animal models
of autoimmune disease and inflammation, to join our R&D team in
San Diego. At Orphagen, our passion is to discover and develop
first-in-class small molecule drugs for the treatment of cancer,
neurodegeneration, and inflammatory disease. Our sweet spot is the
nuclear receptor family of drug targets, a class of transcription
factors that can be modulated by small molecule agonists and
antagonists. We focus on target validation and translational
research using internally-generated lead molecules to characterize
disease model pharmacology and advance novel therapeutic candidates
into clinical development.The Senior Scientist role at Orphagen
provides a unique opportunity to create and test hypotheses that
will drive the development of first-in-class drugs to unexplored
members of the nuclear receptor family.Primary
responsibilities:Develop and implement target validation
strategies, including development of animal models of
gastrointestinal inflammation (e.g. inflammatory bowel disease, GI
graft versus host disease)Integrate in vivo pharmacological data on
first-in-class nuclear receptor-directed lead molecules with
mechanisms of disease, developing hypotheses for characterizing
pre-clinical disease efficacy and safety.Manage related drug
discovery and development projects ranging from molecular
pharmacology assays to non-GLP preclinical safety studies, to
studies mandated for filing of an IND.Support and manage academic
and industry collaborations designed to advance target validation
with Orphagen lead compounds in relevant disease models. Generate,
interpret, and present data to the scientific community, in grant
applications, and to the Orphagen R&D team and
management.Requirements:
Keywords: AmpersandPeople, San Diego , Senior Scientist, Other , San Diego, California
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