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Process Development Scientist

Company: Sorrento Therapeutics
Location: San Diego
Posted on: May 16, 2022

Job Description:

Job DescriptionSalary: DOE+Benefits+OptionsABOUT US Sorrento Therapeutics, Inc. is a clinical stage and commercial biopharmaceutical company focused on delivering innovative and clinically meaningful therapies to address unmet medical needs. Our vision is to leverage our proprietary G-MAB™ library in conjunction with proprietary targeted delivery modalities to generate the next generation of therapeutics for treating cancer, autoimmune, inflammatory, viral and neurodegenerative diseases. These modalities include proprietary chimeric antigen receptor T-cell therapy (CAR-T), dimeric antigen receptor T-cell therapy (DAR-T™), antibody drug conjugates (ADCs), oncolytic virus (Seprehvec™), lymphatic drug targeting (SOFUSA®), as well as bispecific antibody approaches. We are additionally developing pain management solutions, including our clinical candidates resiniferatoxin (RTX) and SEMDEXA™. In response to the global SARS-CoV-2 ("COVID-19") pandemic, we are also developing and conducting clinical studies for potential coronavirus antiviral therapies and vaccines, including Abivertinib, COVI-MSC™, COVI-AMG™, COVIDROPS™, and COVI SHIELD™, and diagnostic test solutions, such as COVISTIX™ and COVITRACK™. We attract smart people who play well with others. We're small enough for your ideas to make a big impact, and large enough to offer you opportunities to grow professionally at any stage of your career. If you're a quick learner, enjoy working in the biotech industry, and share our mission of providing ground-breaking impact to medicine, each other, and our patients, Sorrento Therapeutics is the place for you! Sorrento Therapeutics, Inc. is a federal government contractor and, in compliance with its obligations under current federal regulations and guidance from the Safer Federal Workforce Task Force, Sorrento requires all employees, including newly hired employees, to present proof of vaccination against COVID-19, unless the employee is legally entitled to an accommodation. For further information, please refer to the Safer Federal Workforce Task Force's 2021 Guidance for Federal Contractors and Subcontractors (Updated November 10, 2021), available at: WHAT WE ARE LOOKING FOR: Sorrento Therapeutics ("Sorrento") is seeking an experienced and highly motivated Process Development Scientist with expertise in molecular and cellular biology to join our team. WHAT YOU'LL DO:Develop stable, clonal cell lines for the expression of therapeutic candidate antibodies, optimizing processes in table-top bioreactors and facilitating tech transfer to cGMP facility for antibody production. This role will support the development and characterization of new cell lines and upstream processes. This position will play an integral role in cell line development, optimization of bioreactor process, characterization for recombinant protein expression or cell therapy manufacturing.ESSENTIAL DUTIES AND RESPONSIBILITIES:

  • Plan, execute and analyze experiments, utilizing standard cell biology, biochemical and molecular techniques.
  • Development, characterization, and optimization of cell culture process protocols; Critical analysis of processes for improvement and scalability; General lab tasks including ordering, organizing, and instrument maintenance.
  • Participate in Technology Transfer from process development to manufacturing.
  • Examine data and preparing technical reports, summaries, protocols, and quantitative analysis and ensuring experiments are well documented.
  • Other duties as assigned. EDUCATION AND QUALIFICATIONS:
    • Ph.D. in the fields of cell biology, biochemistry, molecular biology, immunology, bioengineering, and/or cellular signaling.
      • It is essential that the candidate has knowledge and experience of general cell techniques, including transfection, selection, cloning and sub-cloning, small scale antibody production. Prior experience with immune cells is a plus.
      • Experience with a wide range of cellular, biochemical, and molecular biology methodologies, including ELISA, immunoblotting, qPCR, FACS, DNA cloning, CRISPR etc. is preferred.
      • Familiarity with cell culture performance at various conditions is preferred.
      • Experience with design and operation of bioreactors in various scales is a plus.
      • Understanding of process development and GMP is a plus.
      • High level of initiative, ability to work independently, multitask and work well in a fast-paced environment. Excellent writing and communication skills and can write SOP and technical reports.
      • Occasional weekend work for cell culture may be required.
      • Must have excellent interpersonal and communication skills, and ability to lift 25 lbs. is required. YOUR REWARD:
        • Support scientists who are on the leading edge of immunotherapies for the treatment of cancer.
        • Earn a competitive salary that allows you to focus your attention on your passion.
        • A comprehensive benefits package including: medical, dental, vision, life and disability insurance, matching 401k, company paid holidays, and Flexible PTO, plus equity-based compensation. If this sounds like the right career to fit your personality and interests, please apply, we're looking forward to meeting you! Principals only. Recruiters, please do not contact this job poster. Sorrento Therapeutics, Inc. is an Equal Opportunity Employer.

Keywords: Sorrento Therapeutics, San Diego , Process Development Scientist, Other , San Diego, California

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