Process Development Scientist
Company: Sorrento Therapeutics
Location: San Diego
Posted on: May 16, 2022
Job DescriptionSalary: DOE+Benefits+OptionsABOUT US Sorrento
Therapeutics, Inc. is a clinical stage and commercial
biopharmaceutical company focused on delivering innovative and
clinically meaningful therapies to address unmet medical needs. Our
vision is to leverage our proprietary G-MAB™ library in conjunction
with proprietary targeted delivery modalities to generate the next
generation of therapeutics for treating cancer, autoimmune,
inflammatory, viral and neurodegenerative diseases. These
modalities include proprietary chimeric antigen receptor T-cell
therapy (CAR-T), dimeric antigen receptor T-cell therapy (DAR-T™),
antibody drug conjugates (ADCs), oncolytic virus (Seprehvec™),
lymphatic drug targeting (SOFUSA®), as well as bispecific antibody
approaches. We are additionally developing pain management
solutions, including our clinical candidates resiniferatoxin (RTX)
and SEMDEXA™. In response to the global SARS-CoV-2 ("COVID-19")
pandemic, we are also developing and conducting clinical studies
for potential coronavirus antiviral therapies and vaccines,
including Abivertinib, COVI-MSC™, COVI-AMG™, COVIDROPS™, and COVI
SHIELD™, and diagnostic test solutions, such as COVISTIX™ and
COVITRACK™. We attract smart people who play well with others.
We're small enough for your ideas to make a big impact, and large
enough to offer you opportunities to grow professionally at any
stage of your career. If you're a quick learner, enjoy working in
the biotech industry, and share our mission of providing
ground-breaking impact to medicine, each other, and our patients,
Sorrento Therapeutics is the place for you! Sorrento Therapeutics,
Inc. is a federal government contractor and, in compliance with its
obligations under current federal regulations and guidance from the
Safer Federal Workforce Task Force, Sorrento requires all
employees, including newly hired employees, to present proof of
vaccination against COVID-19, unless the employee is legally
entitled to an accommodation. For further information, please refer
to the Safer Federal Workforce Task Force's 2021 Guidance for
Federal Contractors and Subcontractors (Updated November 10, 2021),
available at: WHAT WE ARE LOOKING FOR: Sorrento Therapeutics
("Sorrento") is seeking an experienced and highly motivated Process
Development Scientist with expertise in molecular and cellular
biology to join our team. WHAT YOU'LL DO:Develop stable, clonal
cell lines for the expression of therapeutic candidate antibodies,
optimizing processes in table-top bioreactors and facilitating tech
transfer to cGMP facility for antibody production. This role will
support the development and characterization of new cell lines and
upstream processes. This position will play an integral role in
cell line development, optimization of bioreactor process,
characterization for recombinant protein expression or cell therapy
manufacturing.ESSENTIAL DUTIES AND RESPONSIBILITIES:
- Plan, execute and analyze experiments, utilizing standard cell
biology, biochemical and molecular techniques.
- Development, characterization, and optimization of cell culture
process protocols; Critical analysis of processes for improvement
and scalability; General lab tasks including ordering, organizing,
and instrument maintenance.
- Participate in Technology Transfer from process development to
- Examine data and preparing technical reports, summaries,
protocols, and quantitative analysis and ensuring experiments are
- Other duties as assigned. EDUCATION AND QUALIFICATIONS:
- Ph.D. in the fields of cell biology, biochemistry, molecular
biology, immunology, bioengineering, and/or cellular signaling.
- It is essential that the candidate has knowledge and experience
of general cell techniques, including transfection, selection,
cloning and sub-cloning, small scale antibody production. Prior
experience with immune cells is a plus.
- Experience with a wide range of cellular, biochemical, and
molecular biology methodologies, including ELISA, immunoblotting,
qPCR, FACS, DNA cloning, CRISPR etc. is preferred.
- Familiarity with cell culture performance at various conditions
- Experience with design and operation of bioreactors in various
scales is a plus.
- Understanding of process development and GMP is a plus.
- High level of initiative, ability to work independently,
multitask and work well in a fast-paced environment. Excellent
writing and communication skills and can write SOP and technical
- Occasional weekend work for cell culture may be required.
- Must have excellent interpersonal and communication skills, and
ability to lift 25 lbs. is required. YOUR REWARD:
- Support scientists who are on the leading edge of
immunotherapies for the treatment of cancer.
- Earn a competitive salary that allows you to focus your
attention on your passion.
- A comprehensive benefits package including: medical, dental,
vision, life and disability insurance, matching 401k, company paid
holidays, and Flexible PTO, plus equity-based compensation. If this
sounds like the right career to fit your personality and interests,
please apply, we're looking forward to meeting you! Principals
only. Recruiters, please do not contact this job poster. Sorrento
Therapeutics, Inc. is an Equal Opportunity Employer.
Keywords: Sorrento Therapeutics, San Diego , Process Development Scientist, Other , San Diego, California
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