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Sr. Research Scientist, siRNA/mRNA design and drug discovery

Company: PEAK Technical Staffing USA
Location: San Diego
Posted on: May 16, 2022

Job Description:

Sr. Research Scientist, siRNA/mRNA design and drug discovery Posted: 03/30/2021 Employment Type: Direct Placement Category: Biological Scientists Job Number: 89058 Job Description Senior Research Scientist, siRNA/mRNA design and drug discovery
Reporting To: Sr. Director, Research


Position Objective


Biopharmaceutical company focused on the discovery and development of novel RNA-based therapeutics for intractable diseases. We are currently seeking a talented, highly motivated and independent research scientist with extensive bioinformatics and RNA design experience to join our R&D team. The successful candidate is expected to lead the efforts of siRNA/mRNA drug design, to evaluate the activities of the newly designed RNA drugs in different biological systems, and, as one of key team members, to be actively engaged in the drug discovery activities to address unmet medical needs.

Major Job Functions


  • Lead the efforts on design, modification and optimization of siRNA and/or mRNA drugs for different therapeutic programs
  • Evaluate the activities of the siRNA and/or mRNA drugs using appropriate biological systems, screen and identify the leads
  • Develop novel approaches for siRNA and/or mRNA modifications for potential drug development
  • Mine tangible drug targets from public databases and propose to drug discovery team
  • Present research progress internally and externally and write study reports. Contribute to preparation of IP and IND filings
  • Work closely with cross-functional team members on multiple projects simultaneously

    Education and Experience requirements
    • Ph.D. in biology or chemistry with at least 8 years of therapeutic siRNA and/or mRNA design experience and established knowledge in the area of design of pharmacologically active siRNA and/or mRNA
    • Deep knowledge of related public databases, algorithm and tools/software
    • Demonstrated expertise in functional genomics, molecular phenotypic profiling, and chemistry
    • Thorough knowledge of working with siRNA and/or mRNA screening.
    • A good understanding of the basic pharmacology principles of nucleic acid therapies in term of their efficacy, pharmacokinetics and toxicity
    • Demonstrated innovation with track record in molecular design of novel RNA therapeutics with an ability to be creative and take a proactive approach to problem-solving
    • Ability and desire to work collaboratively on inter-disciplinary projects that span the chemical, analytical, formulation, and biological sciences
    • Strong publications in peer-reviewed scientific journals
    • Proven interpersonal and written/oral communication skills

      ***Level of the position is flexible and commensurate based on candidate' s experience


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Keywords: PEAK Technical Staffing USA, San Diego , Sr. Research Scientist, siRNA/mRNA design and drug discovery, Other , San Diego, California

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