Principal Scientist RNA

Company: Takeda Pharmaceutical
Location: Alpine
Posted on: August 6, 2022

Job Description:

By clicking the "Apply" button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda s Privacy Notice and Terms of Use . I further attest that all information I submit in my employment application is true to the best of my knowledge. Job Description OBJECTIVES/PURPOSE Takeda is seeking an experienced Principal Scientist to join our Drug Discovery Sciences (DDS) department. You will lead RNA target identification and hit identification efforts. You will have a strong record in driving drug discovery programs and stablishing effective in-vitro hit finding and target validation assay strategies. You will build robust collaborations with internal and external partners, and work effectively with biophysicists, structural biologists, chemists, computational chemists and biologists to advance drug discovery programs. You will apply a creative and innovative mindset to identify and solve critical scientific and technical challenges.You will become an integral member of an international, highly multidisciplinary, and science-driven team committed to help patients by delivering innovative therapies against hard-to-drug diseases.Leadership/People:No. of direct reports: 1-2 ACCOUNTABILITIES

• Design and implement effective hit identification and validation strategies using biochemical and cell based assays to accelerate small molecule-RNA programs
• Generate luminescence-based/fluorescence-based mammalian reporter assays (endogenous reporter, minigene reporter, overexpression system, gene KO system) using transient transfection/stable transduction
• Develop and optimize cellular assays using biochemical or imaging-based readouts in a low, medium, or high throughput format for target validation and hit characterization
• Manage resources effectively to accelerate multiple programs simultaneously
• Rigorous data analysis and interpretation
• Develop innovative approaches for the study of RNA modulatorsTechnical/Functional (Line) Expertise
  • Demonstrate well-developed knowledge of related areas such as protein chemistry, cell biology and biophysics
  • Strong understanding of the drug discovery processLeadership
    • Design and direct research strategy and activities to meet program objectives; provide leadership, timelines and contingency plans Decision-making and Autonomy
      • Independently manage workload and expectations
      • Scientifically independent
      • Scientific driver for research strategy that impacts group internally and outside area of function Interaction
        • Initiate and lead external interactions and collaborations
        • Frequent contact with internal and external personnel at various management levels
        • Collaborate with other departments, and disciplines, acting as scientific authority within discipline
        • Serve as senior company / project representative at external conferences, or business meetings EDUCATION, BEHAVIOURAL COMPETENCIES AND SKILLS:
          • PhD degree in a scientific discipline with 6+ years experience , or
          • MS with 12+ years experience, or
          • BS with 14+ years experienceIn accordance with the CO Equal Pay Act, Colorado Applicants Are Not Permitted to Apply.EEO Statement Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law. Locations San Diego, CA Worker Type Employee Worker Sub-Type Regular Time Type Full time

Keywords: Takeda Pharmaceutical, San Diego , Principal Scientist RNA, Other , Alpine, California