Scientist II- SPR-Biophysics
Company: Takeda Pharmaceutical
Location: San Diego
Posted on: August 7, 2022
Job Description:
By clicking the "Apply" button, I understand that my employment
application process with Takeda will commence and that the
information I provide in my application will be processed in line
with Takeda s Privacy Notice and Terms of Use . I further attest
that all information I submit in my employment application is true
to the best of my knowledge. Job Description The Drug Discovery
Sciences (DDS) department at Takeda is looking for an independent
and creative biophysicist with a focus on characterizing small
molecules interaction with proteins and RNAs using SPR methods. You
will be asked to be well-versed in the development of complementary
biophysics techniques (i.e., ITC, TSA) to provide innovative
solutions and address target specific needs and challenges. The
biophysicist will work in a diverse environment with chemists,
structural biologists and pharmacologists in addition to other
biophysicists of the group. ACCOUNTABILITIES
- Manage the development of experiments to support drug discovery
projects aimed at identifying novel small molecules/fragments and
characterizing their interactions with potential drug targets.
- Identify opportunities for SPR, ITC,TSA, MS and other
technologies to investigate both proteins and RNAs.
- Work with other biophysicists in the team to develop
integrative approaches to address specific challenges and
bottlenecks.
- Lead the identification and use of current and latest
biophysics technologies, whether performed internally or accessed
with outside collaborators to improve projects.
- Identify opportunities to collaborate with partners (academic,
biotech and CRO) to enhance in-house capabilities. Leads external
collaborations.
- Participate on teams and provides technical leadership in
biophysics/SPR.
- Present data to project teams; may present data/posters to
external research or scientific community EDUCATION, BEHAVIOURAL
COMPETENCIES AND SKILLS :
- Ph.D. or equivalent with Post Doc in Biophysics or a related
discipline, or
- MS degree with at least 6 years of Biophysics experience,
or
- BS degree with at least 8 years of Biophysics experience, and a
demonstrated working knowledge of Biophysics scientific principles,
or equivalent
- Demonstrated experience with biophysical techniques including,
TSA, SPR, ITC, DLS, and fluorescence spectroscopy.
- Experience studying protein/RNA interactions and macromolecular
complexes as evidenced by quality and quantity of
publications/presentations/inventions.
- Experience with preparation of high-quality protein solutions
for biophysics studies.
- Familiar with Structural Biology methods such as X-ray
crystallography, NMR spectroscopy and Electron microscopy.
- Demonstrated interest in applying biophysical solutions in
fragment-based drug discovery.WHAT TAKEDA CAN OFFER YOU:
- 401(k) with company match and Annual Retirement Contribution
Plan--- Tuition reimbursement --- Company match of charitable
contributions--- Health & Wellness programs including onsite flu
shots and health screenings--- Generous time off for vacation and
the option to purchase additional vacation days--- Community
Outreach ProgramThis job posting excludes Colorado
applicants.Empowering Our People to ShineDiscover more at EEO
Statement Takeda is proud in its commitment to creating a diverse
workforce and providing equal employment opportunities to all
employees and applicants for employment without regard to race,
color, religion, sex, sexual orientation, gender identity, gender
expression, parental status, national origin, age, disability,
citizenship status, genetic information or characteristics, marital
status, status as a Vietnam era veteran, special disabled veteran,
or other protected veteran in accordance with applicable federal,
state and local laws, and any other characteristic protected by
law. Locations San Diego, CA Worker Type Employee Worker Sub-Type
Regular Time Type Full time
Keywords: Takeda Pharmaceutical, San Diego , Scientist II- SPR-Biophysics, Other , San Diego, California
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