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Research Senior Scientist

Company: Takeda Pharmaceutical
Location: Lemon Grove
Posted on: September 23, 2022

Job Description:

By clicking the "Apply" button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda's Privacy Notice and Terms of Use . I further attest that all information I submit in my employment application is true to the best of my knowledge. Job Description Are you looking for a patient-focused company that will inspire you and support your career? If so, be empowered to take charge of your future at Takeda. Join us as a Research Senior Scientist in our San Diego, CA office.At Takeda, we are transforming the pharmaceutical industry through our R&D-driven market leadership and being a values-led company. To do this, we empower our people to realize their potential through life-changing work. Certified as a Global Top Employer, we offer stimulating careers, encourage innovation, and strive for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our global teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world.Here, you will be a vital contributor to our inspiring, bold mission.We are seeking a highly motivated scientist with a background and experience in protein degradation to join Drug Discovery Sciences (DDS) team at Takeda San Diego. The candidate will lead efforts focused on target validation, cellular assay development and mechanism of action studies for targeted protein degradation therapeutics in the areas of Oncology/Immuno-Oncology. The candidate will collaborate with cross-functional teams to advance drug discovery projects.SCOPE

  • Design and conduct in vitro and ex vivo experiments independently to validate new targets for targeted protein degradation
  • Develop cellular assays using various molecular, cellular biology and biochemical methods and innovative technologies to support drug discovery projects
  • Design and conduct studies to understand the mechanisms of action of protein degrader compounds
  • Lead or participate in cross-functional project teams and provide technical leadership in the areas of expertise
  • Collaborate with colleagues in the Drug Discovery Unit and other functional groups of DDS to advance drug discovery projects
  • Generate, analyze and interpret data in appropriate scientific context. Present data and project updates at cross-functional project team meetings.
  • Manage research activities at CROs
  • Document experiments and results in notebooks and in written scientific reportsDIMENSIONS AND ASPECTS
    • Demonstrates well-developed knowledge of related areas such as protein chemistry, cell biology and biophysics
    • Strong understanding of the drug discovery processLeadership
      • Designs and directs research strategy and activities to meet program objectives; provideleadership, timelines and contingency plans Decision-making and Autonomy
        • Independently manages workload and expectations
        • Scientifically independent
        • Scientific driver for research strategy that impacts group internally and outside area of function Interaction
          • Initiates and leads external interactions and collaborations
          • Frequent contact with internal and external personnel at various management levels
          • Collaborates with other departments, and disciplines, acting as scientific authority withindiscipline
          • Serves as senior company / project representative at external conferences, or business meetingsInnovation
            • Determines methods on new assignments; makes strategic recommendations on projects; greater demonstrated independence; may manage junior staffComplexity
              • Ph.D. in Molecular/Cell Biology, Biochemistry or a scientific discipline with 5+ years of postdoctoral experience and 2+ years of relevant industry experience; MS with 10+ years of relevant industry drug discovery experience
              • Significant understanding of protein degradation systems and target protein degradation as a therapeutic modality. Drug discovery experience in the field of protein degradation is desired.
              • Hands-on experience in oncology or immuno-oncology research is required
              • Extensive expertise in developing cellular assays, particularly protein degradation and ubiquitination assays, is required. Experience with CRISPR gene editing or high content imaging is a plus.
              • Excellent communication skills and ability to work collaboratively in a fast-paced, multidisciplinary team setting are requiredWHAT TAKEDA CAN OFFER YOU:--- 401(k) with company match and Annual Retirement Contribution Plan--- Tuition reimbursement --- Company match of charitable contributions--- Health & Wellness programs including onsite flu shots and health screenings--- Generous time off for vacation and the option to purchase additional vacation days--- Community Outreach ProgramsUpdated Takeda U.S. Vaccine Requirement: Absent an approved religious or medical reason, all US office-based and lab-based Takeda employees who work fully on-site or in a hybrid model (as determined by Takeda) must be fully vaccinated to work at a Takeda site or to engage with Takeda colleagues or anyone else on behalf of Takeda. As of the same date, absent an approved religious or medical reason, US field-based employees, employees must be fully vaccinated in order to continue in their current roles. US employees who work at a Takeda manufacturing facility, and those who work at a BioLife center or BioLife lab, may be subject to different guidelines. Candidates are encouraged to speak with their recruiter to seek further information on the applicable guidelines for the Business Unit/Function for which they have applied.This job posting excludes Colorado applicants.Empowering Our People to ShineDiscover more at No Phone Calls or Recruiters Please.EEO Statement Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law. Locations San Diego, CA Worker Type Employee Worker Sub-Type Regular Time Type Full time

Keywords: Takeda Pharmaceutical, San Diego , Research Senior Scientist, Other , Lemon Grove, California

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