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Senior Scientist, Toxicology

Company: Takeda Pharmaceutical
Location: San Ysidro
Posted on: November 25, 2022

Job Description:

By clicking the "Apply" button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda's Privacy Notice and Terms of Use . I further attest that all information I submit in my employment application is true to the best of my knowledge.

Job Description

Are you looking for a patient-focused company that will inspire you and support your career development? If so, be empowered to take charge of your future at Takeda. Become a vital contributor to our inspiring, bold mission of 'safety by design' by joining as a Discovery Toxicologist in the Drug Safety Research and Evaluation division of Preclinical and Translational Sciences at our San Diego, CA site.

Our ideal candidate will have a proven track record in prominent roles supporting cross-functional Drug Discovery project teams. She/he is able to leverage their deep insights into cellular and pathway mechanisms, coupled with knowledge of toxicology in order to provide expert advice and direction to improve the quality of therapeutics. An emphasis on working on gastrointestinal and/or neuroscience disease areas as well as experience in various therapeutic modalities (small molecules, biologics, oligonucleotides, cell therapy) would be a strong plus.


  • As part of the Global Drug Safety Research and Evaluation (DSRE) Team, work in interdisciplinary teams as a 'universal tox rep' within and across the global organization to provide safety support to drug discovery/development teams from target identification to IND submission in Gastrointestinal and Neuroscience therapeutic areas and engage in core activities within the DSRE group
  • Work as part of a team of safety assessment scientists and more broadly DMPK, pathology, pharmacology, and medicinal chemistry experts to implement discovery toxicology strategy to enable the selection and progression of optimized drug candidates
  • Apply novel toxicity mechanism-based assays and integrated models to support early target safety and chemistry evaluation.
  • Career development opportunities exist to represent Takeda Drug Safety Research and Evaluation on internal and external scientific working groups and committees. ACCOUNTABILITIES
    • As toxicology representative to core drug discovery/development project teams, provide expert advice and direction to improve the quality of therapeutics selected for further development based on proactive risk assessment of target- and chemotype-related toxicities
    • Develop comprehensive target safety reviews with risk mitigation plan for early drug discovery project teams based on literature, bioinformatics, and other predictive tools.
    • Apply state of the art in silico, in vitro, and in vivo de-risking strategies to aid in the selection and optimization of large and small molecule therapeutics, as well as new therapeutic modalities
    • Lead the development of early hypothesis-driven investigation into mechanisms of toxicity for the proactive management of potential safety liabilities and communication of impact to teams Qualifications

      • Minimum of PhD in a scientific discipline and 3+ years of experience working at a pharmaceutical company or MS/PharmD with 9+ years of pharmaceutical experience
      • Experience in the drug discovery process from the pharmaceutical industry, with an understanding of scientific partner lines outside of safety and toxicology
      • Demonstrated project team experience at a pharmaceutical company and ability to work effectively in a matrixed, global environment as part of a multidisciplinary team
      • Strong problem solver who is highly organized with the ability to thrive in an environment with rapidly changing priorities.
      • Broad scientific knowledge including pharmacology, toxicology, physiology and biochemistry.
      • Experience in development across mixed modalities, especially oligonucleotides and cell therapy and knowledge of gastrointestinal and/or neuroscience diseases and/or immunology is desired.
      • Strong interpersonal skills with an ability to develop solid, long term relationships and the ability to influence others, and adept at working across multiple cross-functional areas.
      • Excellent oral and written communication skills
      • DABT certification a plus, but not necessary. In accordance with the CO Equal Pay Act, Colorado Applicants Are Not Permitted to Apply.

        • 401(k) with company match and Annual Retirement Contribution Plan
        • Tuition reimbursement
        • Company match of charitable contributions
        • Health & Wellness programs including onsite flu shots and health screenings
        • Generous time off for vacation and the option to purchase additional vacation days EEO Statement

          Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.


          San Diego, CA

          Worker Type

          Worker Sub-Type

          Time Type

          Full time

Keywords: Takeda Pharmaceutical, San Diego , Senior Scientist, Toxicology, Other , San Ysidro, California

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