Senior Scientist I - Novartis Biologics Group

Company: Sandoz International GmbH
Location: San Diego
Posted on: May 26, 2023

Job Description:

If you are curious, scientifically minded, and want to positively impact society by speeding delivery of novel therapies to patients, then look no further. NIBR is the place to be. As a Senior Scientist in the Novartis Biologics Group in San Diego, you will have the opportunity to make a difference. If you have a collaborative nature, a commitment to teamwork across an organization and a relentless focus on improving patient care, we want you to apply.

In this laboratory-based Senior Scientist role, you will apply your hands-on expertise to the bioanalysis of large molecule therapeutics, including gene therapies, cell therapies, antibody-drug conjugates, bi-trispecific/ScFV antibodies, oligonucleotides/siRNA and proteins. You will work with teams of discovery scientists to develop and implement stage-appropriate large molecule assays to support pharmacokinetic, pharmacodynamic and immunogenicity studies for numerous projects as they progress through the research and development pipeline. Additionally, you will contribute to new technology platform evaluations to improve support for challenging new therapeutic modalities.

Purpose
The Protein Sciences group at NIBR San Diego is seeking a highly skilled, motivated, and detailed oriented scientist to support biotherapeutics drug discovery and gene therapies development.

Accountabilities
--- Independently conceives, develops, and executes protein characterization and proteomics-based experiments (particularly targeted workflows in biological matrices)
--- Analyzes and interprets data, provides conclusions, and informs next level experiments
--- Configures, operates, and troubleshoots LC/MS and LC/MS/MS instrumentation
--- Performs a broad range of protein-based sample processing techniques and independently implements new techniques
--- Maintains an accurate and detailed notebook, documents experiments and conclusions


The pay range for this position at commencement of employment is expected to be between $102,400-$153,600 a year; however, base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience. The total compensation package for this position may also include other elements, including a sign-on bonus, restricted stock units, and discretionary awards in addition to a full range of medical, financial, and/or other benefits (including 401(k) eligibility and various paid time off benefits, such as vacation, sick time, and parental leave), dependent on the position offered. Details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an "at-will position" and the Company reserves the right to modify base salary (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors. Diversity & Inclusion / EEO The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. We are committed to building diverse teams, representative of the patients and communities we serve, and we strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential. Qualifications and Skills
--- BS/MS degree in biology sciences, chemistry, analytical chemistry, or related discipline with 2+ years of academic or industry laboratory experience
--- Excellent technical ability, attention to detail, and an eagerness to learn new things
--- Ability to design and conduct experiments under minimal supervision, and to analyze, interpret and communicate data to colleagues
--- Proficiency in standard sample processing techniques for proteomics and general protein analysis (ex. SDS-PAGE, enzymatic digestion, SPE, chemical labeling, immunoprecipitation, phosphorylation enrichment, and fractionation) is essential.
--- Competence in characterizing proteins by LC/MS and LC/MS/MS is required
--- Experience in the set up and operation of HPLCs (particularly nanoLC) and mass spectrometers for protein and peptide analysis.
--- Applied knowledge of MS control and data analysis software (ex. Xcalibur, Analyst, Proteome Discoverer, Skyline, MaxQuant, Sequest, Scaffold, etc)
--- Prior experience in development of targeted analysis of proteins (MRM and PRM) in cells, biological fluids, and tissues is highly desired.
--- Proficiency in cell culture and biochemical techniques are highly desired.
--- Agility and willingness to learn, implement, and teach new bioanalytical techniques to support the evolving portfolio is essential.

Leadership & Culture
Ability to work independently and collaboratively with other researchers; trains other researchers in areas of technical expertise as needed. Communicates results and conclusions to collaborators and offers constructive input for next steps. Steps in to support general lab responsibilities and adapts as necessary to changing project needs.

Why Novartis?
766 million lives were touched by Novartis medicines in 2021, and while we're proud of this, we know there is so much more we could do to help improve and extend people's lives.
We believe new insights, perspectives and ground-breaking solutions can be found at the intersection of medical science and digital innovation. That a diverse, equitable and inclusive environment inspires new ways of working.
We believe our potential can thrive and grow in an unbossed culture underpinned by integrity, curiosity and flexibility. And we can reinvent what's possible, when we collaborate with courage to aggressively and ambitiously tackle the world's toughest medical challenges. Because the greatest risk in life, is the risk of never trying!
Imagine what you could do here at Novartis!

Commitment to Diversity & Inclusion:
Novartis is committed to building an outstanding, inclusive work environment and diverse teams representative of the patients and communities we serve.

Accessibility and Reasonable Accommodations: Individuals in need of a reasonable accommodation due to a medical condition or disability for any part of the application process, or to perform the essential functions of a position, please send an e-mail to tas.nacomms@novartis.com or call +1 (877)395-2339 and let us know the nature of your request and your contact information. Please include the job requisition number in your message.

Join our Novartis Network: If this role is not suitable to your experience or career goals but you wish to stay connected to hear more about Novartis and our career opportunities, join the Novartis Network here: https://talentnetwork.novartis.com/network

Keywords: Sandoz International GmbH, San Diego , Senior Scientist I - Novartis Biologics Group, Other , San Diego, California