Senior Scientist- In Vivo Pharmacology

Company: Healthcare Businesswomen's Association
Location: San Diego
Posted on: May 28, 2023

Job Description:

Job DescriptionOver 900+ clinical trials validate that gene therapies are transforming the practice of medicine. Ready to join a team committed to developing and commercializing gene therapies for patients and families devastated by rare neurological genetic diseases? Novartis is advancing cutting-edge science, starting with our proprietary gene therapy for the treatment of spinal muscular atrophy (SMA). We are in the midst of an incredible journey and are looking for passionate individuals to join us on this important mission.Novartis is dedicated to developing and commercializing novel treatments for patients suffering from rare and life-threatening neurological genetic diseases. Our initial product is a proprietary gene therapy approved by the US Food and Drug Administration for the treatment of pediatric patients with SMA. In addition to developing a treatment for SMA, Novartis also plans to develop other novel treatments for rare neurological diseases, including Rett syndrome and a Friedreich's ataxia.The Neuroscience Disease Area at Novartis is looking for an experienced Scientist with knowledge of neuroscience and histology, to perform tissue-based analysis in support of discovery and validation of disease relevant targets and pathways at the San Diego campus primarily focusing on gene therapies.What you'll be doing:--- Perform high level tasks and play a lead role in animal studies including colony management, dosing, executing in vivo experiments under limited supervision of scientists, and tissue collection related to existing and pipeline products.--- Performs high-level tasks necessary for the husbandry and study of rodent models of disease such as animal identification by marking, breeding, and collection of tissue samples for protein, DNA, or RNA analysis. Plays a lead role and oversees day to day activities of other Research Associates.--- Establish protocols for behavioral studies and execute behavioral testing.--- Partner with lead scientists in research and development to validate, characterize, and distribute mouse models that directly address drug discovery and program validation.--- Work interactively with research and development team to validate, characterize, and distribute mouse models that directly address drug discovery and program validation.--- Executes, tracks, and manages genotyping.--- Leads research associates to organize, schedule and execute experimental work.--- Examine data and prepare technical reports, summaries, protocols, and quantitative analysis, ensuring experiments are well documented and comply with regulatory requirements. Present data to internal project teams. Field questions from research associates and escalate to scientific leadership as necessary. Assist in troubleshooting.--- Maintain and ensure safe laboratory environment and work practices. Follow standard operating procedures (SOP) and IACUC protocols. Help to maintain laboratory.--- Work collaboratively across a dynamic scientific environment.--- Other related duties as assigned. EEO StatementThe Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. We are committed to building diverse teams, representative of the patients and communities we serve, and we strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential.Minimum requirementsWhat you'll bring to the role:--- Bachelor's degree in biomedical research, neuroscience, animal behavior or animal sciences with 4 years related experience or 7 years of equivalent education/experience may be accepted.--- 5 years' experience in rodent handling.--- Excellent oral and written communication skills.--- Proficiency with standard in vivo techniques in rodents, including dosing and sampling routes (e.g., po, ip, sc, iv dosing; cardiac bleeds; necropsy and organ/tumor harvest).--- Preferred - Experience with transcardiac perfusion.--- Preferred - Experience characterizing rodent models of various human diseases with behavioral testing.--- Preferred - Experience with survival and stereotactic surgeries.--- Preferred - Previous industry experience.Why Novartis?766 million lives were touched by Novartis medicines in 2021, and while we're proud of this, we know there is so much more we could do to help improve and extend people's lives.We believe new insights, perspectives and ground-breaking solutions can be found at the intersection of medical science and digital innovation. That a diverse, equitable and inclusive environment inspires new ways of working. We believe our potential can thrive and grow in an unbossed culture underpinned by integrity, curiosity and flexibility. And we can reinvent what's possible, when we collaborate with courage to aggressively and ambitiously tackle the world's toughest medical challenges. Because the greatest risk in life, is the risk of never trying!Imagine what you could do here at Novartis!Commitment to Diversity & Inclusion: Novartis is committed to building an outstanding, inclusive work environment and diverse teams representative of the patients and communities we serve.Accessibility and reasonable accommodationsThe Novartis Group of Companies are committed to working with and providing reasonable accommodation to individuals with disabilities. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application process, or in order to perform the essential functions of a position, please send an e-mail to tas.nacomms@novartis.com call +1 (877)395-2339 and let us know the nature of your request and your contact information. Please include the job requisition number in your message.https://www.novartis.com/careers/careers-research/notice-all-applicants-us-job-openingsVaccine Policy: While Novartis does not require vaccination at this time, for certain Novartis sites in the US all associates and candidates may be required to either upload an image of their COVID-19 vaccine card demonstrating proof of full vaccination for COVID-19 (or other similar evidence of vaccination) or proof of a negative COVID-19 test taken by the associate or candidate within the past seven days to enter any of our sites and/or customer office or healthcare facility, as well as prior to participating in other work related off-site meetings. Employees working in customer-facing roles must adhere to and comply with customers' (such as hospitals, physician offices, etc.) credentialing guidelines, which may require vaccination. As required by applicable law, Novartis will consider requests for reasonable accommodation for those unable to be vaccinated. This requirement is subject to applicable state and local laws and may not be applicable to employees working in certain jurisdictions.

Keywords: Healthcare Businesswomen's Association, San Diego , Senior Scientist- In Vivo Pharmacology, Other , San Diego, California