In Vivo Scientist

Company: Joul--
Location: San Diego
Posted on: September 19, 2023

Job Description:

Job Title: In Vivo ScientistLocation: San Diego, CACompensation: $75.00- $81.05Type: Contract --Overview Leading Biopharmaceutical company looking for an experienced In vivo Scientist. Ideal candidate should have 5+ years of experience with in vivo studies, molecular biology techniques, xenograft and syngeneic models, and data analysis and presentation. --Responsibilities

• Independently design, plan, execute and interpret complex in vivo studies focused on identifying small and large candidate molecules and ADCs within the area of oncology.
• Formulation of small and/or large molecules for in vivo studies.
• Evaluation of pathway biomarkers and endpoints from in vivo studies via techniques such as flow cytometry, qPCR, IHC, ELISA, Mesoscale, Flow cytometry and Western blots.
• Plan, execute and interpret pharmacokinetic/pharmacodynamic studies in acute and chronic disease models.
• Data presentation to multidisciplinary discovery teams.
• Participate in the evaluation of new targets.
• Identification of risks within function and development of contingencies plans to mitigate risk.
• Lead and manage the pharmacology staff assigned to them.
• Interface with cross-functional teams and represent pharmacology on discovery teams and lead sub-teams. --Requirements
  • Bachelor???s Degree with 5+ years of academic and / or industry experience
  • Master???s Degree with 3+ years of academic and / or industry experience
  • Ph.D. or equivalent advanced degree in the Life Sciences with No experience necessary
  • 5+ years of in vivo studies
  • 5+ molecular biology techniques
  • 5+ xenograft and syngeneic tumor models
  • 5+ years Data analysis and presentation Preferred Qualifications
    • Proven track record in validating and implementing animal models for testing cancer therapies including xenograft and syngeneic tumor models. Experience with advanced humanized models is a plus.
    • In vivo skills include animal handling, dosing of small or large molecules, and ADC sample preparation, small animal surgeries, tissue sample collection, imaging modalities.
    • In vivo target validation and experience with more complex xenotransplantation, transgenic and knockout models is a plus.
    • Proficiency in laboratory bench skills such as ELISAs, Western blots, Mesoscale, qPCR, Nanostring, Flow cytometry, and/or histology is required. Experience with immunophenotyping of cells from various matrices is a plus.
    • Proven track record of good experimental design, in-depth data analysis and interpretation based on strong scientific rationale.
    • Detail oriented and able to problem solve and offer potential solutions.
    • Excellent written and oral communication skills. Ability to write protocols and technical reports with precision.
    • Ability to work in a fast-paced dynamic team environment; flexibility to adapt to changes with a positive attitude and independently collaborate across teams, requiring excellent communication skills, both written and verbal, with strong interpersonal skills. Supervisory experience is a plus.
    • Interface with cross-functional team members and present to multidisciplinary teams.
    • Computer skills: Advanced knowledge of Excel, Word, PowerPoint, FlowJo and GraphPad Prism. Experience with StudyLog software is a plus.
    • Local candidates preferred. BenefitsSystem One offers eligible employees health and welfare benefits coverage options, including medical, dental, vision, spending accounts, life insurance, voluntary plans, and participation in a 401(k) plan.--

Keywords: Joul--, San Diego , In Vivo Scientist, Other , San Diego, California