In Vivo Scientist
Company: Joul--
Location: San Diego
Posted on: September 19, 2023
Job Description:
Job Title: In Vivo ScientistLocation: San Diego, CACompensation:
$75.00- $81.05Type: Contract --Overview Leading Biopharmaceutical
company looking for an experienced In vivo Scientist. Ideal
candidate should have 5+ years of experience with in vivo studies,
molecular biology techniques, xenograft and syngeneic models, and
data analysis and presentation. --Responsibilities
- Independently design, plan, execute and interpret complex in
vivo studies focused on identifying small and large candidate
molecules and ADCs within the area of oncology.
- Formulation of small and/or large molecules for in vivo
studies.
- Evaluation of pathway biomarkers and endpoints from in vivo
studies via techniques such as flow cytometry, qPCR, IHC, ELISA,
Mesoscale, Flow cytometry and Western blots.
- Plan, execute and interpret pharmacokinetic/pharmacodynamic
studies in acute and chronic disease models.
- Data presentation to multidisciplinary discovery teams.
- Participate in the evaluation of new targets.
- Identification of risks within function and development of
contingencies plans to mitigate risk.
- Lead and manage the pharmacology staff assigned to them.
- Interface with cross-functional teams and represent
pharmacology on discovery teams and lead sub-teams. --Requirements
- Bachelor???s Degree with 5+ years of academic and / or industry
experience
- Master???s Degree with 3+ years of academic and / or industry
experience
- Ph.D. or equivalent advanced degree in the Life Sciences with
No experience necessary
- 5+ years of in vivo studies
- 5+ molecular biology techniques
- 5+ xenograft and syngeneic tumor models
- 5+ years Data analysis and presentation Preferred
Qualifications
- Proven track record in validating and implementing animal
models for testing cancer therapies including xenograft and
syngeneic tumor models. Experience with advanced humanized models
is a plus.
- In vivo skills include animal handling, dosing of small or
large molecules, and ADC sample preparation, small animal
surgeries, tissue sample collection, imaging modalities.
- In vivo target validation and experience with more complex
xenotransplantation, transgenic and knockout models is a plus.
- Proficiency in laboratory bench skills such as ELISAs, Western
blots, Mesoscale, qPCR, Nanostring, Flow cytometry, and/or
histology is required. Experience with immunophenotyping of cells
from various matrices is a plus.
- Proven track record of good experimental design, in-depth data
analysis and interpretation based on strong scientific
rationale.
- Detail oriented and able to problem solve and offer potential
solutions.
- Excellent written and oral communication skills. Ability to
write protocols and technical reports with precision.
- Ability to work in a fast-paced dynamic team environment;
flexibility to adapt to changes with a positive attitude and
independently collaborate across teams, requiring excellent
communication skills, both written and verbal, with strong
interpersonal skills. Supervisory experience is a plus.
- Interface with cross-functional team members and present to
multidisciplinary teams.
- Computer skills: Advanced knowledge of Excel, Word, PowerPoint,
FlowJo and GraphPad Prism. Experience with StudyLog software is a
plus.
- Local candidates preferred. BenefitsSystem One offers eligible
employees health and welfare benefits coverage options, including
medical, dental, vision, spending accounts, life insurance,
voluntary plans, and participation in a 401(k) plan.--
Keywords: Joul--, San Diego , In Vivo Scientist, Other , San Diego, California
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