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AD/Sr. Principal Scientist - CADD

Company: Knewin
Location: San Diego
Posted on: February 10, 2024

Job Description:

Hybrid - San Diego siteThe Computer-Aided Drug Discovery (CADD) group in San Diego is seeking an AD/Senior Principal Scientist to join our talented and innovative drug discovery team. NIBR research teams deliver clinically successful medicines across a broad range of mechanisms of action including small molecules, peptides, RNAs, protein degradation, molecular glues, transient covalent inhibitors, and kinetic stabilization of drug-target complexes. In all our endeavors, we build on our vast knowledgebase of over 20 million activity measurements, internal proprietary structural database, a global CADD team and the partnership and expertise of over 5,000 scientists with a variety of expert skills.Your Key Responsibilities: Leverage your CADD expertise to engage and influence multidisciplinary project teams for effective decision-making from hit identification through to candidate nomination Drive compound optimization cycles by participation in rational drug design and synthesis prioritization efforts via advanced scoring methods (active learning and ML model development, free-energy perturbation or alternate scoring method), in multi-objective fashionDevelop, improve and implement efficient computational workflows that can be distributed to our global CADD teamParticipate in strategic level discussions for CADD impact and growthMentor within, as well as outside of, the CADD group, including those CADD members who directly report to youInitiate drug discovery efforts by proposing novel targets / modalities, evaluating target druggability and executing in silico hit generation, triage and expansion methodologiesKeep abreast of scientific developments and interact with internal and external scientists to integrate novel insights into computational approaches for drug discovery
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Keywords: Knewin, San Diego , AD/Sr. Principal Scientist - CADD, Other , San Diego, California

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