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Scientist, DNA-Encoded Library - Discovery Chemistry

Company: Disability Solutions
Location: San Diego
Posted on: June 2, 2024

Job Description:

Janssen Research & Development, LLC, a member of Johnson & Johnson's Family of Companies, is recruiting for a Scientist, DNA-Encoded Library - Discovery Chemistry, located in San Diego, CA. At Janssen, we never stop working toward a future where disease is a thing of the past. We're the Pharmaceutical Companies of Johnson & Johnson, and you can count on us to keep working tirelessly to make that future a reality for patients everywhere, by fighting sickness with science, improving access with ingenuity, and healing hopelessness with heart. We focus on areas of medicine where we can make the biggest difference: Cardiovascular & Metabolism, Immunology, Infectious Diseases & Vaccines, Neuroscience, Oncology, and Pulmonary Arterial Hypertension. Visit us: We are seeking a Scientist to support our DNA-encoded library (DEL) platform. In this laboratory-based position, this individual will join our DNA-Encoded Library Chemistry group and work closely with members of our broader DEL selection, DEL analytical, and DEL informatics teams to enable our full end-to-end DEL screen workflow. As part of the core DEL team, you will also work closely with Janssen project teams across a variety of targets and therapeutic areas to interpret DEL screening results, coordinate hit resynthesis and influence the early hit-to-lead trajectory from DEL screening campaigns as well as other screening modalities in our integrated hit finding workflow. A passion to learn new laboratory techniques and scientific areas, and the ability to thrive in a multidisciplinary, results oriented environment are key attributes. Principal Responsibilities:

  • Performing DNA-based labwork independently such as: aqueous chemical reactions on DNA-small molecule conjugates; DNA ligation or other molecular biology techniques; purification of DNA conjugates with High-Performance Liquid Chromatography (HPLC) or other techniques; analysis of DNA-small molecule conjugate compositions through mass spectrometry, electrophoresis, DNA quantitation and other relevant methods.
  • Designing new Janssen DELs, sourcing materials required for productions, and interfacing with external chemistry and DEL synthesis resources to support the builds.
  • Supporting DEL screening campaigns through initial planning with the DEL core and project teams, designing chemical tools, analyzing decoded DEL data, and coordinating DEL hit resynthesis and early follow up with internal and external CRO synthetic resources
  • Evaluating and developing new DEL technologies either internally or through collaboration with key external partners.
  • Presenting data and project status in internal meetings, peer-reviewed journals and scientific conferences

Keywords: Disability Solutions, San Diego , Scientist, DNA-Encoded Library - Discovery Chemistry, Other , San Diego, California

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