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RESEARCH ASSOCIATE I-III IN ANTIBODY DRUG CONJUGATION (ADC) PROCESS DE

Company: Sorrento Therapeutics, Inc.
Location: Del Mar
Posted on: February 15, 2018

Job Description:

ABOUT US Levena Biopharma, a wholly owned subsidiary of Sorrento Therapeutics(NASDAQ: SRNE), is a leading expert in antibody drug conjugate (ADC) technology, utilizing our own proprietary site-specific conjugation technology and an extensive catalog of linker-toxin compounds. As a CDMO service provider, we have established cGMP manufacturing facilities to accelerate the complete ADC drug development process: from linker-toxin production to conjugation, characterization, and final processing. Currently, we have several exciting programs in development at our San Diego, CA location that are aimed toward addressing unmet challenges in oncology and other disease areas. A Research Associate I-III position is available immediately in the ADC Process Development and Manufacturing group. JOB DESCRIPTION The successful candidate will prepare ADCs using both general and proprietary bioconjugation methodology with the goal toward process optimization and development. He or she must therefore be independently proficient in a variety of synthetic, analytical and purification techniques related to antibodies and antibody conjugates. A particular emphasis is placed on a thorough mastery of analytical and preparative chromatography, especially hydrophobic interaction chromatography (HIC), ion exchange (IEX), and size-exclusion chromatography (SEC). Experience with using tangential flow filtration (TFF) techniques is a plus. The successful candidate will be a detail oriented individual who can manage and organize data on different projects. He or she will be able to multi-task and problem solve while maintaining a clear sense of priorities and focus. The successful candidate must possess strong oral and written communication skills while working efficiently to satisfy strict timelines and deliverables. As Levena is a team-oriented, multi-disciplinary environment, the successful candidate will be expected to engage in regular interaction, as needed, with the Synthetic Chemistry, Biology, and Analytical Development teams. YOUR RESPONSIBILITIES The synthesis, purification, and characterization of ADCs with an emphasis on applying DOE principals toward conjugation process development and optimization. Possess a versatile technical proficiency in antibody and ADC handling at multiple (microgram to gram) scales Maintain a strong mastery of analytical and preparative chromatography including, but not limited to, HIC, IEX, and SEC methods, in addition to TFF processing. The individual will be able to frequently communicate results both internally and externally through presentations and formal technical reports. Maintain a legible, accurate, and detailed record of all relevant data and testing in the laboratory notebook, including specific protocols and procedures being utilized. The individual will be required to assist in method trouble shooting and the creation and/or revision of SOPs. Perform laboratory work in a safe and compliant manner at all times. QUALIFICATIONS M.S. with 2+ years or B.A./B.S. with 3+ years of experience in antibody bioconjugation, ADC development, or related research area, preferably in a pharmaceutical, biopharmaceutical or biotech organization. Thorough knowledge and experience in analytical and preparative chromatography including, but not limited to, HIC, IEX, and SEC methods, along with TFF purification. Must have strong problem solving, interpersonal, teamwork, project management and communication skills (oral & written). Must be flexible, able to handle multiple projects simultaneously, and work efficiently to be able to satisfy specific timelines and deliverables. YOUR REWARD The chance to grow your career in a dynamic, growing, and collaborative environment on the cutting edge of cancer immunotherapy development. Earn a competitive salary while allowing you to focus your attention on innovative science A comprehensive benefits package including: full medical (HMO, PPO, HSA, and FSA options), dental, vision, life and disability insurance, company-matching 401(k), 10 paid holidays, three weeks paid vacation, stock options, and an onsite gym. CONTACT US If this sounds like the right career to fit your personality and interests, we're looking forward to meeting you. Please attach your CV or resume and note the following job title in the subject line: RA_ADC_HL, and email to Principals only. Recruiters, please don't contact this job poster. About Sorrento Therapeutics, Inc. Sorrento is an antibody-centric, clinical stage biopharmaceutical company developing new treatments for cancer, inflammation and autoimmune diseases. Sorrento's lead products are multiple late-stage biosimilar and biobetter antibodies, as well as clinical CAR-T therapies targeting solid tumors. Principals only. Recruiters, please don't contact this job poster. Sorrento Therapeutics, Inc. is an Equal Opportunity Employer

Keywords: Sorrento Therapeutics, Inc., San Diego, RESEARCH ASSOCIATE I-III IN ANTIBODY DRUG CONJUGATION (ADC) PROCESS DE, Other, Del Mar, California

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