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18-0049 Scientist II/ Sr. Scientist-Nucleic Acid & Protein Characterization

Company: Synthetic Genomics
Location: La Jolla
Posted on: June 14, 2018

Job Description:

OverviewAt Synthetic Genomics, Inc., we are dedicated to developing and commercializing genomic-driven solutions to address global challenges. We are currently seeking a Scientist II/Senior Scientist in our Analytical Chemistry department with experience in nucleic acids and protein isolation and characterization to join our fast-growing, dynamic and collaborative team in La Jolla, CA.The Scientist II/Senior Scientist will provide cross-functional technical expertise and method development for nucleic acid/protein isolation and characterization. The successful candidate will have strong background in general analytical chemistry with an emphasis on large molecules and be well versed in methods and instrumentation used for the isolation, characterization and release testing of nucleic acids and proteins. This is a hands-on"at the bench" role focused on method development and cross-functional communication that requires designing and conducting laboratory experiments, sample handling, data acquisition, data interpretation, data reporting and method validation/documentation. In depth knowledge in the development of bio-molecular interaction assays using commercially available biosensor based equipment in areas including but not limited to: titer quantification, affinity determination, protein-protein binding kinetics and protein-DNA/RNA interactions is also desired.Required SkillsDemonstrated success with developing methods necessary to purify and characterize nucleic acids and proteinsExpert knowledge of current instrumentation and software used to purify and characterize nucleic acids and proteinsIn-depth expertise in mass spectrometry especially in relation to characterization of large moleculesHands on experience and demonstrated expertise with Agilent Q-TOF LC/MS and Thermo Orbitrap mass spectrometersExpertise in operation and use of a wide array of analytical instrumentationExperience with sample preparation from complex biological matricesExperience with biomolecular interaction based method developmentHands on expertise and in-depth technical knowledge with current biomolecular interaction instrumentation, software and methodsHands-on experience with Pall ForteBio instruments and software is a strong plusExperience with GLP documentationHands-on LIMS experienceAbility to generate detailed analytical test methods, and optimized/validated standard operating procedures for both complex and routine methodsAbility to work efficiently and collaboratively in a fast-paced team environment, and to mentor and train othersStrong organizational skills, orientation to detail, ability to multitask and prioritize effectivelyCritical thinking, highly self-motivated, flexible and adaptable to changing priorities and resourcesMust possess excellent interpersonal skills and have strong oral and written communication abilities to facilitate communication with and support of cross-functional collaborations across diverse research programsRequired ExperienceA Ph.D. in Analytical Chemistry, Biophysics, Biochemistry, Organic Chemistry, Physical Chemistry, or other relevant discipline with a minimum of 2 years of postdoctoral research experience and 4 or more years of hands-on experience preferably in an industrial settingA strong diverse knowledge of synthetic biology, nucleic acids chemistry, biophysics, biochemistry, inorganic chemistry, organic chemistry and physical chemistryExperience with purification and in-depth analytical characterization of nucleic acids and proteinsProven ability to operate, maintain, and troubleshoot versatile analytical instrumentation to maintain high standards of performanceProficiency with statistical data analysis softwareIND123

Keywords: Synthetic Genomics, San Diego, 18-0049 Scientist II/ Sr. Scientist-Nucleic Acid & Protein Characterization, Other, La Jolla, California

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