Scientist II, Molecular and Cell Biology
Location: San Diego
Posted on: October 12, 2018
Description Celgene is a global biopharmaceutical company leading the way in medical innovation to help patients live longer, better lives. Our purpose as a company is to discover and develop therapies that will change the course of human health. We value our passion for patients, ?quest for innovation, spirit of independence and love of challenge. With a presence in more than 70 countries, and growing - we look for talented people to grow our business, advance our science and contribute to our unique culture. The Molecular and Cellular Pharmacology Group in the Protein Homeostasis Thematic Center of Excellence (PH TCoE) focuses on delivering novel cancer therapeutics by engaging E3 ubiquitin ligases for targeted protein degradation. We are seeking a motivated PhD Scientist with broad experience in and deep understanding of the ubiquitin-proteasome system (UPS) to participate in drug discovery research. The successful candidate will work collaboratively in a multi-disciplinary environment to 1) explore E3 ligase biology enabling identification of drug targets; 2) develop and implement robust cellular assays to support discovery of small molecules as clinical development candidates; and 3) design and execute in vitro studies that further our understanding of the mechanisms of novel compounds. Responsibilities include studying the biology of various E3 ligases and utilizing cellular models to design relevant assays in support of SAR, mechanism of action, biomarker selection, and disease positioning. The successful candidate will work within discovery project teams and with scientists across different functional areas and be expected to present his or her work at project team meetings and to senior research leadership. Protein Homeostasis at Celgene The PH TCoE at Celgene is one of the fundamental research and early development engines delivering therapeutics to patients. As a thematic center, the PH TCoE is agnostic to therapeutic modality or disease area. The group integrates discovery research through translational and early clinical development and focuses on numerous aspects of protein homeostasis including the ubiquitin-proteasome system, protein translation, and RNA processing and stability. This thematic focus allows the group to capitalize on the cutting edge science that underpins the action of the company?s most advanced drugs. Not being bound by disease area or therapeutic modality creates a very dynamic, exciting and creative environment that exploits excellent science in biology, biochemistry, structural biology, computational biology and translational development. Responsibilities will include but are not limited to the following: + Explore E3 ligase biology enabling identification of drug targets. + Generate relevant disease cell models using molecular tools to support cell-based assay development for drug discovery. + Develop and implement relevant cell based assays to support identification, optimization, and characterization of novel chemical matter and their targets. + Independently design and conduct essential experiments in cell biology, molecular biology with good quality and high reproducibility. + Analyze and present data in an organized and timely manner. + Work within and support biology needs for drug discovery teams Requirements: + Ph.D. with at least 4 years of post-doctoral experience in molecular and cell biology. + Comprehensive and in-depth knowledge in ubiquitin E3 ligase and UPS biology and/or in cancer biology are plus. + Extensive experience with various molecular and cellular biology technologies including molecular cloning, mammalian cell culture, immunofluorescence, lenti-virus production and transduction, gene expression analysis is required. Hands-on experience and deep-understanding of CRISPR-based gene editing (Knock-in and Knock-out) and RNAi and generating corresponding engineered cell lines is preferred. + Experience in HTS of cell based assay is a plus. + Highly motivated and strong team player with a high degree of independence. + Ability to work in a fast-paced dynamic team environment; flexibility to adapt to changes with a positive attitude. + Excellent communication, presentation, collaboration and organizational skills are required. + Data analysis skills and experience with a variety of scientific software applications are required. + Capability to stay focused and deliver high quality data in a timely and well organized manner. + Innovative and critical thinking to generate testable hypotheses and execute experiments. + Good data management skills required. #LI-POST BIO-US Celgene is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Celgene complies with all applicable national, state and local laws governing nondiscrimination in employment as well as employment eligibility verification requirements of the Immigration and Nationality Act. All applicants must have authorization to work for Celgene in the U.S.COMMITTED TO IMPROVING THE LIVES OF PATIENTS WORLDWIDE At Celgene, we seek to deliver truly innovative and life-changing drugs for our patients. Our vision as a company is to build a major global biopharmaceutical corporation while focusing on the discovery, the development, and the commercialization of products for the treatment of cancer and other severe, immune, inflammatory conditions. ?At Celgene, we seek to deliver truly innovative and life-changing drugs for our patients.? There are more than 300 clinical trials at major medical centers using compounds from Celgene. Investigational compounds are being studied for patients with incurable hematological and solid tumor cancers, including multiple myeloma, myelodysplastic syndromes, chronic lymphocytic leukemia (CLL), non-Hodgkin?s lymphoma (NHL), triple-negative breast cancer and pancreatic cancer. As committed as we are to clinical accomplishment, we are equally committed to patient support, which is a guiding principle at Celgene. We believe all who can benefit from our discoveries should have the opportunity to do so. Celgene puts patients first with industry-leading programs that provide information, support and access to our innovative therapies.
Keywords: Celgene, San Diego , Scientist II, Molecular and Cell Biology, Other , San Diego, California
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