the smart solution for San Diego jobs

Postdoctoral Fellow in Cell Cycle Biology: Systems Pharmacology

Company: Pfizer
Location: La Jolla
Posted on: April 18, 2019

Job Description:


Pfizer Oncology R&D is working to change the trajectory of cancer by translating breakthrough discoveries in cancer research into the best medicines imaginable for cancer patients. The Cell Cycle Biology group is assembling a cross-disciplinary team of postdocs with expertise in biochemistry, cell biology, mathematics, and systems pharmacology. Based in La Jolla, California, this team will work collaboratively to leverage unprecedented chemical and biological discovery platforms to further our understanding of basic cell cycle control mechanisms in normal and pathological contexts.

The interrogation of proprietary big data sets that span the preclinical to clinical development continuum for Pfizer cell cycle inhibitor programs has returned novel observations that form the basis for a Postdoctoral Fellow-directed research initiative. The successful candidate will use computational genomics and functional genomics tools to evaluate the robustness of existing and emerging hypothesis relating to cell cycle regulation, and apply captured knowledge to develop novel combination therapies anchored upon the Pfizer cell cycle inhibitor franchise. The Postdoctoral Fellow will be embedded with a dynamic and multidisciplinary research team that consists of other Fellows and senior scientists within the Pfizer Oncology Research Division.


  • Collaborate closely with experimental and computational scientists to explore fundamental research questions with an emphasis on novel discoveries that will result in high impact publications
  • Participate in design of targeted in vitro and in vivo experiments to address key questions about the role and molecular interactions and functional roles of canonical and non-conical CDK/cyclin complexes
  • Develop and utilize cell-based and/or disease model systems to functionally validate experimental observations
  • Organize, interpret, and analyze data, and identify areas where key knowledge is lacking.
  • Proactively seek out new information in the literature and incorporate this into their scientific hypothesis and experimental plan
  • Effectively communicate data and results at internal and external meetings/conferences
  • Good understanding of cell cycle and signaling pathways and interest in CRISPR technologies, metabolomics, proteomics, transcriptomics.
  • Produce high impact publications in peer reviewed journals


    • Recent Ph.D. in molecular biology, cell biology, or a related field
    • Familiarity with formulating experimentally tractable hypotheses from mining omics-based data sets
    • Significant experience with an array of molecular and cell biology methods, including cloning and vector construction, qPCR-based expression analysis, development of cell-based assays, mammalian cell culture and lentiviral production, ELISA, western blot, RNAi and CRISPR/Cas9 functional genomic methods, and/or fluorescence microscopy
    • Excellent communication and organizational skills, willingness to learn new skills, and demonstrated ability to work effectively as part of a team
    • Demonstrated research productivity by first-author publications in peer-reviewed journals


      Lifting, sitting, standing, walking, bending, ability to perform mathematical calculations and ability to perform complex data analysis

      EEO & Employment Eligibility

      Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

      Sunshine Act

      Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

      Eligible for Employee Referral Bonus

      Pfizer is an equal opportunity employer and complies with all applicable equal employment opportunity legislation in each jurisdiction in which it operates.

Keywords: Pfizer, San Diego , Postdoctoral Fellow in Cell Cycle Biology: Systems Pharmacology, Other , La Jolla, California

Click here to apply!

Didn't find what you're looking for? Search again!

I'm looking for
in category

Other Other Jobs

Current College Students - Stores Executive Intern: South Florida
Description: One of the world's leading and most recognized brands comes to life in our stores, where guests are still captivated by everything that made them fall in love with Target. Our approximately 1800 locations (more...)
Company: Target
Location: San Diego
Posted on: 04/24/2019

Real Estate Associate - Licensed Only
Description: You may have seen our signs or heard good things about how we do business, but here is what you really need to know about Keller Williams Realty. We are 100 dedicated to helping you build your real estate (more...)
Company: Keller Williams Realty
Location: San Diego
Posted on: 04/24/2019

Current College Students - Stores Executive Intern - Little Rock, AR
Description: One of the world's leading and most recognized brands comes to life in our stores, where guests are still captivated by everything that made them fall in love with Target. Our approximately 1800 locations (more...)
Company: Target
Location: San Diego
Posted on: 04/24/2019

Real Estate Associate - License Required
Description: Finding the right real estate brokerage to build your career is one of the most important decisions you will make. It is imperative you align yourself with a company that can provide you the best opportunity (more...)
Company: Keller Williams Realty
Location: Carlsbad
Posted on: 04/24/2019

Associate Landscape Designer (2)
Description: Landscape 13 br Associate Landscape Designer 2 San Diego, CA and may work from home Draw conceptual
Company: McCullough Landscape Architecture, Inc.
Location: San Diego
Posted on: 04/24/2019

Structural Revit Modeler
Description: Structural Revit Modeler br If you are a Structural Revit Modeler with experience, please read on br Top Reasons to Work with Us br Competitive Salary and Benefit package, large
Company: CyberCoders
Location: San Diego
Posted on: 04/24/2019

Current College Students - Mechanistic & Investigative Tox Intern
Description: Caring for the world, one person at a time has inspired and united the people of Johnson Johnson for over 130 years. We embrace research and science -- bringing innovative ideas, products and services (more...)
Company: Johnson & Johnson
Location: San Diego
Posted on: 04/24/2019

Senior Proposal Development Professional
Description: We are looking for Senior Proposal Development Professionals in the San Diego area. Willingness to travel nationally is a plus. br br SMA has a continuing requirement for highly motivated, proposal (more...)
Company: SM&A
Location: San Diego
Posted on: 04/24/2019

Current College Students - Summer Operations Intern
Description: Are you a college or high school student ready to demonstrate your skill in a job that helps you gain great experience Love doing whatever it takes, and performing a variety of tasks Want the best summer (more...)
Company: Galileo Camps
Location: Carlsbad
Posted on: 04/24/2019

Allied Universal Professional Security Officer
Description: OverviewWe are North America's leading security services provider with over 200,000 phenomenal employees. For all full-time positions, we offer medical, dental and vision coverage, life insurance, 401K, (more...)
Company: Allied Universal Security
Location: San Diego
Posted on: 04/24/2019

Log In or Create An Account

Get the latest California jobs by following @recnetCA on Twitter!

San Diego RSS job feeds