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Postdoctoral Fellow in Cell Cycle Biology: Systems Pharmacology

Company: Pfizer
Location: La Jolla
Posted on: April 18, 2019

Job Description:

ROLE SUMMARY

Pfizer Oncology R&D is working to change the trajectory of cancer by translating breakthrough discoveries in cancer research into the best medicines imaginable for cancer patients. The Cell Cycle Biology group is assembling a cross-disciplinary team of postdocs with expertise in biochemistry, cell biology, mathematics, and systems pharmacology. Based in La Jolla, California, this team will work collaboratively to leverage unprecedented chemical and biological discovery platforms to further our understanding of basic cell cycle control mechanisms in normal and pathological contexts.

The interrogation of proprietary big data sets that span the preclinical to clinical development continuum for Pfizer cell cycle inhibitor programs has returned novel observations that form the basis for a Postdoctoral Fellow-directed research initiative. The successful candidate will use computational genomics and functional genomics tools to evaluate the robustness of existing and emerging hypothesis relating to cell cycle regulation, and apply captured knowledge to develop novel combination therapies anchored upon the Pfizer cell cycle inhibitor franchise. The Postdoctoral Fellow will be embedded with a dynamic and multidisciplinary research team that consists of other Fellows and senior scientists within the Pfizer Oncology Research Division.

ROLE RESPONSIBILITIES


  • Collaborate closely with experimental and computational scientists to explore fundamental research questions with an emphasis on novel discoveries that will result in high impact publications
  • Participate in design of targeted in vitro and in vivo experiments to address key questions about the role and molecular interactions and functional roles of canonical and non-conical CDK/cyclin complexes
  • Develop and utilize cell-based and/or disease model systems to functionally validate experimental observations
  • Organize, interpret, and analyze data, and identify areas where key knowledge is lacking.
  • Proactively seek out new information in the literature and incorporate this into their scientific hypothesis and experimental plan
  • Effectively communicate data and results at internal and external meetings/conferences
  • Good understanding of cell cycle and signaling pathways and interest in CRISPR technologies, metabolomics, proteomics, transcriptomics.
  • Produce high impact publications in peer reviewed journals

    BASIC QUALIFICATIONS

    • Recent Ph.D. in molecular biology, cell biology, or a related field
    • Familiarity with formulating experimentally tractable hypotheses from mining omics-based data sets
    • Significant experience with an array of molecular and cell biology methods, including cloning and vector construction, qPCR-based expression analysis, development of cell-based assays, mammalian cell culture and lentiviral production, ELISA, western blot, RNAi and CRISPR/Cas9 functional genomic methods, and/or fluorescence microscopy
    • Excellent communication and organizational skills, willingness to learn new skills, and demonstrated ability to work effectively as part of a team
    • Demonstrated research productivity by first-author publications in peer-reviewed journals

      PHYSICAL/MENTAL REQUIREMENTS

      Lifting, sitting, standing, walking, bending, ability to perform mathematical calculations and ability to perform complex data analysis

      EEO & Employment Eligibility

      Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

      Sunshine Act

      Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

      Eligible for Employee Referral Bonus

      Pfizer is an equal opportunity employer and complies with all applicable equal employment opportunity legislation in each jurisdiction in which it operates.

Keywords: Pfizer, San Diego , Postdoctoral Fellow in Cell Cycle Biology: Systems Pharmacology, Other , La Jolla, California

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