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Research Scientist, In Vivo Research & Engineered Cell Biology

Company: Angiocrine Bioscience, Inc.
Location: San Diego
Posted on: May 19, 2019

Job Description:

About Angiocrine Bioscience, Inc. Angiocrine Bioscience Inc. (AB) is a privately held, San Diego, CA based clinical-stage biopharmaceutical company with proprietary technologies consisting of an internally generated pipeline of human engineered endothelial cells (E-CEL). E-CEL cells have multiple potential applications related to regeneration of vital organs and tissues throughout the body. AB has two IND clearances with one on-going Phase 1b study and two planned to start in 2019. The AB team is united and fueled by its passion and sense of urgency to bring new, breakthrough engineered cell therapies to patients suffering from dire, often life-threatening medical conditions Position Role & Responsibilities:

  • Conduct pre-clinical in vivo studies, some requiring microsurgery, which test our pre-clinical engineered cell product candidates
  • Analyze data collected from in vivo studies performed
  • Participate or lead in design of in vivo studies
  • Conduct and analyze 2-D and 3-D engineered cell culture and assay experiments relevant to engineered cell product candidates Position Requirements:
    • Works collaboratively with fellow AB team members, especially with the AB Research Team and the AB Project Management Team
    • Enjoys a fast-paced environment where data-based changes are a constant and where proactive 'can do' attitude, sense of urgency and friendly personalities are prized.
    • A successful candidate must have extensive hands-on experience in performing in-vivo animal modeling work for various potential indications.
    • A track record of the ability to learn new in vivo surgical and modeling techniques is essential
    • Possesses skills related to wet-lab cell-therapy translational research (e.g., various cell culture techniques, cell sorting, flow cytometry, qPCR, fluorescent microscopy, antibody assays, intra-cellular signaling detection).
    • Previous experience with the following in vivo procedures: Tissue extraction and dissection, IV injection (tail-vein, jugular, retro-orbital) and surgical proficiency in murine models (not limited to a specific area: e.g. intratracheal administration, partial hepatectomy, partial pneumonectomy, vascular ligation and/or thrombosis, gastrointestinal and/or vascular anastamoses, etc)
    • Education: Master's degree or PhD in cell biology, molecular biology, biochemistry, immunology or related field and 5 or more years post-graduate hands-on laboratory experience (post-doc or industry experience) covering both in vitro and in vivo work. Additional Desired Skills and Knowledge
      • Applicants with experience in various micro-surgical procedures in murine models is desired. The applicant's ability to not only perform such surgical procedures, but also demonstrate knowledge and experience in designing such in vivo experiments would be highly regarded.
      • Applicants with expertise in organ regeneration modeling related to inflammatory and autoimmune disease and injuries would also be preferred.
      • Preference for candidates with experience in the fields of tissue regeneration and/or microvascular biology and vascular niches.
      • Demonstrated expertise in translational in vivo cellular biology involving research and/or product development of cell therapy product is highly desired. Additional Information: This position is based in San Diego, CA. Angiocrine is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

Keywords: Angiocrine Bioscience, Inc., San Diego , Research Scientist, In Vivo Research & Engineered Cell Biology, Other , San Diego, California

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