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Temporary Scientist I, Formulation

Company: Vertex
Location: San Diego
Posted on: July 15, 2019

Job Description:

Job Description:Vertex Pharmaceuticals Incorporated seeks an innovative and self-motivated scientist to drive preclinical formulation efforts at our site in San Diego, California. Drawing on a thorough knowledge of experimental physical chemistry, the incumbent will support drug discovery projects at the level of lead optimization/ preclinical at the site. Key deliverables will include, among others: i) formulations (solution, suspension, emulsion, and solid dispersions) of small molecule chemical entities to support PK, pharmacology, and toxicology studies on a daily basis in order to enable IV and Oral PK studies in various animal species, ii) physicochemical characterization (e.g., solubility, crystallinity, DSC, TGA, physical and chemical stability, form evaluations), iii) permeation studies using Cacco-2 cells to assess in vitro absorption potential of Vertex compounds by maintaining cell cultures, and performing permeability studies, and iv) cross-site and cross-functional communication to ensure alignment between the activities among various stakeholders.

The successful candidate will join Formulation Development (FD), the functional area in Pharmaceutical Sciences responsible for preformulation and preclinical formulation development of our drug molecules across the discovery and development pipeline.


Key Responsibilities

  • Develop IV/PO/SC formulations (solution, suspension, emulsion, and solid dispersions) of small molecule chemical entities to support PK and toxicity studies
  • Discover novel solid forms (i.e., polymorphs, salts, co-crystals, and amorphous dispersions) of pre-clinical candidates
  • Evaluate experimentally the physicochemical properties (e.g., solubility/stability in bio-relevant media) of those solid forms
  • Cell culturing and permeation studies
  • Document experimental procedures in accordance with existing standard operating procedures and develop best practices
  • Qualification:
  • Hands-on experience preparing formulations (by various routes of administration including oral, intravenous, intraperitoneal) of small molecule drug candidates
  • Expertise with XRPD, DSC, TGA, DVS, HPLC, and other solid state analytical techniques
  • Ability to develop strong partnerships/relationships across groups
  • Sufficient written and oral communication skills
  • Demonstrated self-motivation
    Preferred Qualifications
  • M.Sc. (or equivalent degree) and + 3 years of experience in the Pharmaceutical Industry (in preclinical formulation)

Keywords: Vertex, San Diego , Temporary Scientist I, Formulation, Other , San Diego, California

Click here to apply!

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