Company: Pfizer Inc.
Location: La Jolla
Posted on: October 14, 2019
We seek an accomplished Principal Scientist level oncology/immune
oncology scientist to join the in vivo pharmacology group within
Oncology Research & Development (ORD) in La Jolla, California. The
successful candidate will join a dynamic team of scientists in the
Oncology In Vivo Pharmacology Group, playing a leading role in
guiding project teams in the appropriate planning and use of models
of cancer to evaluate new drug candidates, mechanisms and
The Principal Scientist/In Vivo Lead will participate in
pre-clinical drug discovery and development projects with a focus
on immuno-oncology while also contributing to projects related to
signal transduction, targeted therapeutics, and epigenetics. The
successful candidate will be responsible for working with project
teams to design, plan and execute an in vivo strategy to ensure
efficient and effective project decision-making. They will also be
a key contributor to the In Vivo Committee, responsible for
presenting study plans and obtaining peer input for protocol
finalization and approval to meet research project objectives. The
individual will directly supervise laboratory staff that make up an
in vivo team responsible for study performance and data analysis
and play a role in the Pharmacology Department strategy. The
Principal Scientist will provide technical and scientific expertise
in in vivo pharmacology across ORD to enable target identification,
validation, prioritization and efficient drug discovery. Ideal
applicants will possess excellent communication, leadership and
organizational skills, critical problem-solving abilities, and a
commitment to excellence.
- Establish scientific in vivo strategy and study plans for drug
- Serve as the in vivo pharmacology lead for several drug
- Works within multi-functional teams to support target
identification, validation, drug discovery and combination
- Works across In vivo teams in a highly collaborative manner,
sharing expertise and resources to meet study needs across In Vivo
- Design and conduct in vivo studies to evaluate and establish
efficacy, PK/PD relationship, combination strategy, biomarker
identification and analysis.
- Develop and characterize new in vivo mouse models, including
syngeneic tumor and genetically engineered mouse (GEM) models, to
study biologic mechanisms and support exploration of novel cancer
immune therapeutics and targeted Interpretation, presentation and
documentation of experiments as well as preparation of
- The Principal Scientist will generate and be accountable for
the necessary Animal Use Protocols that ensures team members comply
with all regulatory requirements and internal policies.
- Facilitate and lead the development and execution of ancillary
in vitro assays necessary to maximize value of the contribution by
the in vivo team.
- Responsible for contribution to relevant in vivo sections of
study reports and regulatory documents i.e. IND filings.Written and
verbal presentation of results within a multidisciplinary team
environment. Ensure that projects have all critical in vivo data to
enable project stage dependent decisions.Publication of results in
scientific peer-reviewed journals and presentations at internal,
national, and international meetings.
- Ph.D. in Cancer Biology, Immunology, Biochemistry, Genetics or
equivalent experience in a related discipline with > 5 years
industry experience with technical and scientific experience in
drug discovery and preclinical development.
- Experience in collaborative research in Oncology drug discovery
- Expertise in animal models of human cancers as well as strong
publication record or evidence of equivalent achievements in
industry are desired.
- Expertise with GEMM and humanized models highly desirable.Hands
on in vivo (eg: IV, PO dosing, blood/tissue collection)and ex vivo
skills (flow cytometry, western blot, ELISA).
- Excellent written and oral communication and presentation
skills in English. Proficiency in all common office and scientific
- Supervisory experience is a significant plus
Pfizer reports payments and other transfers of value to health care
providers as required by federal and state transparency laws and
implementing regulations. These laws and regulations require Pfizer
to provide government agencies with information such as a health
care provider's name, address and the type of payments or other
value received, generally for public disclosure. Subject to further
legal review and statutory or regulatory clarification, which
Pfizer intends to pursue, reimbursement of recruiting expenses for
licensed physicians may constitute a reportable transfer of value
under the federal transparency law commonly known as the Sunshine
Act. Therefore, if you are a licensed physician who incurs
recruiting expenses as a result of interviewing with Pfizer that we
pay or reimburse, your name, address and the amount of payments
made currently will be reported to the government. If you have
questions regarding this matter, please do not hesitate to contact
your Talent Acquisition representative.
EEO & Employment Eligibility
Pfizer is committed to equal opportunity in the terms and
conditions of employment for all employees and job applicants
without regard to race, color, religion, sex, sexual orientation,
age, gender identity or gender expression, national origin,
disability or veteran status. Pfizer also complies with all
applicable national, state and local laws governing
nondiscrimination in employment as well as work authorization and
employment eligibility verification requirements of the Immigration
and Nationality Act and IRCA. Pfizer is an E-Verify employer.
Other Job Details:
- Eligible for Relocation Package
- Eligible for Employee Referral Bonus
N (Other) (United States of America)
Pfizer is an equal opportunity employer and complies with all
applicable equal employment opportunity legislation in each
jurisdiction in which it operates.
Keywords: Pfizer Inc., San Diego , Principal Scientist, Other , La Jolla, California
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