Advisor - Protein Mass Spectrometry
Location: San Diego
Posted on: June 23, 2025
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Job Description:
At Lilly, we unite caring with discovery to make life better for
people around the world. We are a global healthcare leader
headquartered in Indianapolis, Indiana. Our employees around the
world work to discover and bring life-changing medicines to those
who need them, improve the understanding and management of disease,
and give back to our communities through philanthropy and
volunteerism. We give our best effort to our work, and we put
people first. We’re looking for people who are determined to make
life better for people around the world. The Protein Biosciences
group at the Lilly Biotechnology Center in San Diego is seeking a
motivated and detail-oriented mass spec scientist to join our
Protein Mass Spectrometry Laboratory in Antibody Discovery. The
successful candidate will contribute to the characterization of
therapeutic proteins using state-of-the-art LC/MS systems as well
as various stability indicating assays. This position is ideal for
someone with a strong foundation in protein biochemistry and
hands-on experience in an analytical mass spec laboratory.
Responsibilities: Develop and perform LC-MS and LC-MS/MS analyses
of bispecific antibodies, antigens, fusion proteins, peptides,
conjugates, and other biologics. Execute intact mass, clipping
analysis, peptide mapping, disulfide bond mapping, and host cell
analyses independently. Support structural elucidation and product
characterization. Develop and conduct antibody based stability
study and serum stability study using mass spec, cIEF, CE-SDS,
labchip, HPLC (SEC, CEX, AEX), and related biophysical techniques.
Perform high-throughput (HT) analytical screening assays using
Hamilton and other automated liquid handler systems for sample
preparation. Operate, calibrate, and maintain LC and LC/MS systems
(e.g., Agilent Q-tof and Tof, Thermo High Resolution MS systems)
and other analytical instruments (MAURICE, nanodrop, Lunatic)
Document experimental results in electronic lab notebooks (ELN) and
contribute to technical reports and presentations. Collaborate with
cross-functional teams including protein engineering, computation,
and various discovery groups. Basic Qualifications: A PhD degree in
biology, chemistry, biochemistry, or a similar field with a minimum
of 1-3 years of relevant industry experience (Post-Doc experience
accepted). Must have strong method development skills in mas spec,
CE-SDS, and cIEF Additional Skills and Preferences: Must have
experience with GeneData Expressionist data processing. Highly
organized, detail-oriented, and self-motivated. Strong
communication and presentation skills with a collaborative mindset.
Willingness to learn and grow in a dynamic and fast-paced discovery
team. Experience with sample preparation for MS analysis of
proteins and peptides. Working knowledge of chromatography and
Agilent and Thermo MS instrumentation. Must be familiar with
Agilent Q-Tof, Thermo QE, Exploris 480, and Waters Cyclic IMS Must
have a strong understanding of protein/antibody structure and
post-translational modifications Lilly is dedicated to helping
individuals with disabilities to actively engage in the workforce,
ensuring equal opportunities when vying for positions. If you
require accommodation to submit a resume for a position at Lilly,
please complete the accommodation request form (
https://careers.lilly.com/us/en/workplace-accommodation ) for
further assistance. Please note this is for individuals to request
an accommodation as part of the application process and any other
correspondence will not receive a response. Lilly is proud to be an
EEO Employer and does not discriminate on the basis of age, race,
color, religion, gender identity, sex, gender expression, sexual
orientation, genetic information, ancestry, national origin,
protected veteran status, disability, or any other legally
protected status. Our employee resource groups (ERGs) offer strong
support networks for their members and are open to all employees.
Our current groups include: Africa, Middle East, Central Asia
Network, Black Employees at Lilly, Chinese Culture Network,
Japanese International Leadership Network (JILN), Lilly India
Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ
Allies), Veterans Leadership Network (VLN), Women’s Initiative for
Leading at Lilly (WILL), enAble (for people with disabilities).
Learn more about all of our groups. Actual compensation will depend
on a candidate’s education, experience, skills, and geographic
location. The anticipated wage for this position is $133,500 -
$217,800 Full-time equivalent employees also will be eligible for a
company bonus (depending, in part, on company and individual
performance). In addition, Lilly offers a comprehensive benefit
program to eligible employees, including eligibility to participate
in a company-sponsored 401(k); pension; vacation benefits;
eligibility for medical, dental, vision and prescription drug
benefits; flexible benefits (e.g., healthcare and/or dependent day
care flexible spending accounts); life insurance and death
benefits; certain time off and leave of absence benefits; and
well-being benefits (e.g., employee assistance program, fitness
benefits, and employee clubs and activities).Lilly reserves the
right to amend, modify, or terminate its compensation and benefit
programs in its sole discretion and Lilly’s compensation practices
and guidelines will apply regarding the details of any promotion or
transfer of Lilly employees. WeAreLilly
Keywords: , San Diego , Advisor - Protein Mass Spectrometry, Science, Research & Development , San Diego, California
