Clinical Biomarker Lead

Company: Janux Therapeutics
Location: San Diego
Posted on: February 14, 2026

Job Description:

Job Description Job Description Janux Therapeutics is seeking a Clinical Biomarker Lead to join our Translational group and contribute to the end-to-end planning and execution of clinical biomarker strategy for our early-stage clinical programs. This individual will closely work with the biomarker operations and research team to ensure timely clinical sample evaluation and generate data analytics strategy to derive critical insights from clinical trial data to inform strategic decision-making. The ideal candidate will bring an in-depth understanding of oncology and/ or immunology and clinical-translational research experience. ESSENTIAL FUNCTIONS AND RESPONSIBILITIES Lead end-to-end execution of the clinical biomarker strategy to support Janux’s oncology and autoimmune clinical programs Organize and maintain clinical biomarker and bioanalytical datasets and individual patient profiles for clinical programs. Perform high throughput data analytics of, translational, and clinical datasets to identify and validate potential biomarkers of response/resistance to TRACTr, TRACIr, and/or ARM treatments. Integrate functional biological readouts with patient’s clinicopathological features to contribute to patient selection strategies for clinical programs. Collaborate with Biomarker and clinical operation teams to ensure end-to-end sample tracking and maintain oversight on all sample related timelines including subsequent data collection and distribution. Manage multiple specialty vendor labs and maintain strong oversight on deliverables (proposals, timelines, experimental design, data analyses and reporting). Prepare and present data. Collaborate with internal Clinical Science and Research/ Immunology teams to evaluate data analytic approaches and ensure meaningful insights in the delivery. Perform in-depth scientific literature review to help address critical questions relating to target biology, clinical relevance, and associated assays. Work cross-functionally with Research, Clinical and CMC teams to drive scientific programs and deliver critical insights to help inform decision-making across the portfolio. EDUCATION, EXPERIENCE, KNOWLEDGE, SKILLS AND ABILITIES Ph.D. in Immunology, Clinical/Health Sciences, Bioinformatics, or related scientific discipline with 4 years of experience, preferably in an industry setting, with an emphasis in clinical biomarker analysis or translational medicine. Strong understanding and experience working in immuno-oncology and/or solid tumor oncology with hands-on experience in designing, developing, and interpreting clinical biomarker datasets. Competence with data analysis tools (Excel, GraphPad). Proficiency in data handling and visualization with R or Python is preferred. Demonstrated ability to create impactful data visualization outputs and present meaningful insights. Experience working with EDC systems and data listings is highly preferred. Experience with Good Clinical Practice (GCP) principles and studies transitioning into clinical trials. Experience working with external CROs (due diligence, proposals, oversight, project management, data analyses, and reporting) is highly preferred. Strong analytical and critical thinking skills with the ability to work in a fast-paced environment. Excellent written and oral communication skills. In addition to a competitive base salary ranging from $150,000 to $163,000, we offer stock options, a stock purchase plan (ESPP) and a target bonus. Janux also provides a comprehensive benefits package for our employees and their families, which includes medical, dental, vision, and supplemental disability insurance. Please note that the base salary range is a guideline, and individual total compensation will vary based on factors such as qualifications, skill level, competencies, internal equity and work location. Job Type: Full-time Benefits: · Annual bonus program · Incentive stock option plan · 401k plan with flat non-elective employer contribution · Comprehensive medical insurance with 90-100% employer-paid premiums · Dental and vision insurance · HSA, FSA, and supplemental insurance plans (life, disability, accident, critical illness, hospital indemnity) · Unlimited PTO · Generous holiday schedule; includes summer and winter company shutdown · Relocation assistance Schedule: · Monday to Friday Work authorization: · United States (Required) Additional Compensation: · Annual targeted bonus % Work Location: · On site (San Diego, CA) EQUAL OPPORTUNITY EMPLOYER: Janux Therapeutics, Inc. is an equal opportunity employer that is committed to providing a work environment free of harassment and discrimination based upon a protected category, as well as an environment free from retaliation for protected activity. Notice to Recruiters and Third-Party Agencies The Talent Acquisition team manages the recruitment and employment process for Janux. To protect the interests of all parties involved, Janux will only accept resumes from a recruiter once a fully-executed search agreement is in place. Agencies are hereby specifically directed not to contact Janux employees directly in an attempt to present candidates. Janux will consider any candidate for whom an Agency and/or Recruiter has submitted an unsolicited resume to have been referred, free of any charges or fees. We may use artificial intelligence (AI) tools to support parts of the hiring process, such as reviewing applications, analyzing resumes, or assessing responses. These tools assist our recruitment team but do not replace human judgment. Final hiring decisions are ultimately made by humans. If you would like more information about how your data is processed, please contact us.

Keywords: Janux Therapeutics, San Diego , Clinical Biomarker Lead, Science, Research & Development , San Diego, California