Synthetic Organic Chemist

Company: Mirati Therapeutics
Location: San Diego
Posted on: February 16, 2020

Job Description:

Mirati is seeking synthetic organic chemists to join the Drug Discovery group at the Associate Scientist level. We are looking for candidates with modern synthetic methodologies, purification, characterization and lab techniques. This is a highly collaborative role where you will form strong relationships with scientists in all our internal groups. In addition, you will need excellent communication skills and the ability to to adapt to a fast-paced environment.RESPONSIBILITIES:

• Utilize cutting-edge synthetic methodologies and techniques to design and execute efficient syntheses of target compounds for existing chemical series and novel series
• Conduct multi-step synthesis and optimization through effective reaction planning, troubleshooting, and systematic analysis.
• Maintain all appropriate legal and corporate standards for lab safety and hazardous material management; execute daily chemistry operations with an approach designed to minimize risks and hazard waste streams.
• Synthesize singleton analogs (
• Purify and characterize compounds using a variety of techniques including chromatography, crystallization, trituration, LCMS, NMR, etc.
• Engage with CMC and early development teams to facilitate IND-enabling activities for drug substance to ensure a seamless transition from late discovery to early development with internal accountability and flexibility.
• Help set up and manage a synthetic chemistry lab.
• Maintain the lab instruments including HPLC, ISCO, lyophilizer etc.
• Maintain lab notebook, instrument and inventory records in accord with department guidance and regulatory requirements
• Prepare and present summaries of work for department and project meetings.
• Participate in the preparation of publications and patent applications related to Mirati's portfolio of projects. REQUIREMENTS:
  • A Bachelor's or Master's degree with 0-5 years of synthetic organic experience, preferably in the pharma or biotech sector.
  • Flexibility in adapting methods/skills according to evolving project priorities.
  • Demonstrated knowledge of modern synthetic, laboratory and analytical techniques.
  • Excellent oral and written communication skills, including preparation of presentations.

Keywords: Mirati Therapeutics, San Diego , Synthetic Organic Chemist, Other , San Diego, California